SonoLiver分析软件在前列腺内腺结节诊断中的应用价值  

The application value of SonoLiver software in differential diagnosis of the nodules within prostatic inner gland

作　　者：黄鑫[1] 孙彬[1] 陈辽[1] 胡伟[1] 张瑶 陈文卫[1] Huang Xin;Sun Bin;Chen Liao;Hu Wei;Zhang Yao;Chen Wenwei(Department of Ultrasound,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院超声影像科,430060

出　　处：《中华超声影像学杂志》2019年第2期144-150,共7页Chinese Journal of Ultrasonography

摘　　要：目的探讨SonoLiver分析软件的动态血管模式(DVP)和超声造影(CEUS)鉴别诊断前列腺内腺结节的价值。方法选取于我院超声影像科就诊的前列腺疾病患者,共104例前列腺内腺结节经直肠穿刺活检获得病理学诊断结果,其中前列腺癌(PCa)29例,前列腺良性增生(BPH)26例,前列腺良性增生伴高级别上皮内瘤变(HGPIN)结节25个,前列腺良性增生伴低级别上皮内瘤(LGPIN)结节24个。应用SonoLiver软件分析结节CEUS过程,获取DVP类型和造影参数。结果四组患者血清前列腺特异性抗原(PSA)水平、结节最大径的差异均具有统计学意义(P<0.05)。PCa组上升时间(RT)、达峰时间(TTP)、平均渡越时间(mTT)在四组中最小,而峰值强度(IMAX)在四组中最大。TTP和IMAX在四组间差异具有统计学意义(P<0.05)。PCa组44.8%的结节DVP类型为暖冷双色系(Ⅰ型),而HGPIN组以暖色系(Ⅱ型)为主(40.0%),但两组间的差异无统计学意义(P>0.05)。LGPIN和BPH结节DVP类型均以冷暖双色系(Ⅳ型)和冷色系(Ⅲ型)为主,差异无统计学意义(P>0.05)。四组前列腺结节DVP类型的差异具有统计学意义(P<0.05)。结论SonoLiver分析软件对于前列腺内腺结节的鉴别诊断具有一定的参考价值。Objective To provide objective basis for the diagnosis on nodules of prostatic inner gland by SonoLiver software with the dynamic vascular pattern (DVP) and the parameters of contrast-enhanced ultrasonography(CEUS). Methods In a reprospective study, CEUS was performed in 104 cases with nodules of prostatic inner gland that were divided into four groups including the benign prostatic hypertrophy(BPH) group (n=26) and prostate cancer(PCa) group (n=29), the others in high grade prostate intraepithelial neoplasia(HGPIN, n=25) and low grade prostate intraepithelial neoplasia(LGPIN, n=24) that developed from BPH. The SonoLiver software was used to analyze the CEUS of nodules to get the DVP and parameters of CEUS. Results Among the four groups, the prostate specific antigen (PSA) level and nodule maximal size were significant different(P<0.05). Rise time(RT), time to peak(TTP) and mean transit time(mTT) of PCa group were highest among the four groups, while maximum intensity(IMAX) was the lowest. The differences of TTP, IMAX among the four groups were statistically significant (P<0.05). In the PCa group, 44.8% of nodules were warm-cold colour. The DVP type in HGPIN group was mainly only warm colour(40.0%), but the difference of DVP between PCa and HGPIN group was not significant(P>0.05). The nodules in BPH and LGPIN group mostly were cold-warm colour, also as only cold colour(P>0.05). The difference of DVP among the four groups was significant (P<0.05). Conclusions The application of SonoLiver software with DVP and parameters of CEUS is valuable to diagnose the nodules of prostatic inner gland.

关 键 词：超声造影 前列腺肿瘤 诊断 动态血管模式 

分 类 号：R697.3[医药卫生—泌尿科学] R445.1[医药卫生—外科学]