Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications  

作　　者：Fan Yu Song Guo Te Li Jie Ran Wei Zhao Dengwen Li Min Liu Xiumin Yan Xiaoyong Yang Xueliang Zhu Jun Zhou 

机构地区：[1]State Key Laboratory of Medicinal Chemical Biology,Colleges of Life Sciences and Pharmacy,Nankai University,300071 Tianjin,China [2]Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences,Shandong Normal University,250014 Jinan, Shandong,China [3]State Key Laboratory of Cell Biology,Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,200031 Shanghai,China [4]Department of Cellular and Molecular Physiology,Yale University School of Medicine,New Haven,CT 06520, USA

出　　处：《Cell Research》2019年第2期171-173,共3页细胞研究（英文版）

基　　金：grants from the National Key R&D Program of China (2017YFA0503500);the National Natural Science Foundation of Chma (31730050, 31701169,31741039,and 31471262).

摘　　要：Dear Editor Diabetes is a chronic metabolic disease that has become a major epidemic worldwide. High blood glucose is thought to be the primary cause of most devastating long-term complications of diabetes. In addition to strict glycemic control,a number of therapeutics have been used to slow down the progression of diabetic complications. However,a majority of current therapies for most diabetic complications have shown disappointing results in clinical trials.Because these complications arise from a number of pathological processes,targets for early interventions that could lead to effective treatments are largely unknown.

关 键 词：DEAR Editor Diabetes chronic metabolic disease EPIDEMIC WORLDWIDE 

分 类 号：Q[生物学]