62例急性期布鲁菌病患者的流行病学特征及血液学变化  

Epidemiological characteristics and hematological changes in 62 patients with acute brucellosis

作　　者：王静 邵磊 张叶 邢春燕 王欣 Wang Jing;Shao Lei;Zhang Ye;Xing Chunyan;Wang Xin(Department of Respiration,Jinan Central Hospital Affiliated to Shandong University,Jinan 250000,Chino;Department of Obstetrics,Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250021,China)

机构地区：[1]山东大学附属济南市中心医院呼吸科,250000 [2]山东大学附属山东省立医院产科,济南250021

出　　处：《中华地方病学杂志》2019年第2期152-154,共3页Chinese Journal of Endemiology

基　　金：山东省医药卫生发展计划项目(2016WSA01083).

摘　　要：目的探讨急性期布鲁菌病(简称布病)患者的流行病学特城及血液学变化。方法采用前瞻性设计,以2013-2016年在山东大学附属济南市中心医院确诊的急性期布病患者为观察对象,对发病人群、分布等流行病学特征及血红蛋白(HB)、红细胞计数(RBC)、白细胞计数(WBC)、血小板计数(PLT)、平均红细胞体积(MCV)、平均红细胞血红蛋白量(MCH)、平均红细胞血红蛋白浓度(MCHC)等血液学变化进行分析。结果共收集急性期布病患者62例,其中男性45例、女性17例,男、女性别比为2.65∶1.00,年龄(42.37±12.99)岁;农村居民39例、城市居民23例。62例急性期布病患者中,HB减少(贫血)15例(24.19%),RBC减少38例(61.29%),WBC减少9例(14.52%),PLT减少6例(9.68%)。15例急性期布病贫血患者的MCV为(86.12±4.00)fl,MCH为(28.08±2.01)pg,MCHC为(325.27±14.48)g/L,均在正常参考值范围内,为正常细胞性贫血。结论急性期布病患者中,男性发病例数高于女性,以农村患者为主;血液学变化主要表现为HB、RBC、WBC、PLT减少。Objective To explore the epidemiological characteristics and hematological changes in patients with acute brucellosis. Methods Using forward-looking design, patients with confirmed diagnosis of acute brucellosis in Jinan Central Hospital Affiliated to Shandong University from 2013 to 2016 were involved in the study. Epidemiological characteristics (such as population and distribution) and hematological changes [such as hemoglobin (HB), red blood cell count (RBC), white blood cell count (WBC), platelet count (PLT), mean erythrocyte volume (MCV), mean erythrocyte hemoglobin (MCH), and mean erythrocyte hemoglobin concentration (MCHC)] were studied. Results Totally 62 patients with acute brucellosis were collected, including 45 males and 17 females, the gender ratio of male and female was 2.65 ∶ 1.00, with an average age of (42.37 ± 12.99) years old;and rural patients (39 cases) were higher than urban patients (23 cases). Among 62 patients with acute brucellosis, HB decreased (anemia) in 15 cases (24.19%), RBC decreased in 38 cases (61.29%), WBC decreased in 9 cases (14.52%), and PLT decreased in 6 cases (9.68%). Fifteen patients with acute brucellosis developed anemia symptoms, MCV was (86.12 ± 4.00) fl, MCH was (28.08 ± 2.01) pg, and MCHC was (325.27 ± 14.48) g/L, all of these values were within the normal reference range, indicating that they were normal cell anemia. Conclusions Of the patients with acute brucellosis, male patients are higher than female patients, and they are mainly rural residents. Hematological changes are mainly manifested as decreased HB, RBC, WBC, PLT.

关 键 词：布鲁杆菌病 流行病学 血液学 

分 类 号：R516.7[医药卫生—内科学]