氟中毒骨相研究的新动物模型--斑马鱼  

A new animal model for skeletal fluorosis--zebrafish

作　　者：范玉梅(综述)[1] 高彦辉(审校者)[1] Fan Yumei;Gao Yanhui(Institute for Endemic Fluorosis Control,Center for Endemic Disease Control,Chinese Center for Disease Control an[i Prevention,Key Laboratory of Etiology and Epidemiology for National Health and Family Planning Commission (23618504),Key Laboratory of Trace Elements and Human Health of Heilongjiang Province,Key Laboratory of Etiology and Epidemiology for Heilongjiang Province Colleges and Universities,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学中国疾病预防控制冲心地方病控制中心地氟病防治研究所,国家卫生计生委病因流行病学重点实验室(23618504)黑龙江省微量元素与人类健康重点实验室,黑龙江省普通高校病因流行病学重点实验室,150081

出　　处：《中华地方病学杂志》2019年第2期169-172,共4页Chinese Journal of Endemiology

基　　金：国家自然科学基金(81172605);黑龙江省杰出青年科学基金(JC2015018).

摘　　要：斑马鱼作为一种新型的脊椎动物模型,目前被广泛应用于骨骼疾病研究,特别是在骨质疏松方面已经取得了较为显著的研究成果。在氟中毒研究领域,鱼类模型比传统的动物模型更为敏感。本文将结合鱼类氟中毒研究成果,介绍斑马鱼的生物学特性和成骨特点,概述斑马鱼在骨骼研究方面的应用现状,并对其在氟中毒骨相研究领域的应用进行展望。As a new animal model of vertebrate, zebrafish has been widely used in the research of bone diseases, especially in osteoporosis. In the field of fluorosis research, existing studies have shown that fish are more sensitive than traditional animal models. In this paper, combine with fish fluorosis research results, the biological characteristics and osteogenic characteristics of zebrafish are introduced, the application status of zebrafish in bone research is summarized, and the application of zebrafish in the field of skeletal fluorosis is prospected.

关 键 词：斑马鱼 骨 氟骨症 动物模垂 

分 类 号：R681[医药卫生—骨科学]