镍催化还原偶联反应构筑C(sp^2)—C(sp^2)/C(sp^2)—C(sp^3)键的研究进展  

Recent Advance in Ni-Catalyzed Reductive Cross-Coupling to Construct C(sp^2)—C(sp^2) and C(sp^2)—C(sp^3) Bonds

作　　者：李娅琼 范玉航 贾乾发 Li Yaqiong;Fan Yuhang;Jia Qianfa(College of Chemistry and Chemical Engineering, Yangtze Normal University, Chongqing 408100)

机构地区：[1]长江师范学院化学化工学院

出　　处：《有机化学》2019年第2期350-362,共13页Chinese Journal of Organic Chemistry

基　　金：长江师范学院科研(No.2017KYQD24)资助项目~~

摘　　要：亲电试剂的还原偶联反应避免了有机金属试剂的制备与使用,对各类官能团拥有极好的兼容性,为C-C键的构筑提供了一类重要的方法.近些年来,该反应的研究取得了突破性进展,实现了一系列C(sp^2)-X与C(sp^3)-X亲电试剂参与的交叉偶联反应.主要针对镍催化亲电试剂交叉偶联反应构筑C(sp^2)-C(sp^2)和C(sp^2)-C(sp^3)键的研究展开综述,详细介绍了各种偶联反应及其反应机制.The cross-coupling of two electrophiles has emerged as an important and attractive method for carbon-carbon bond formation. This synthetic protocol avoids preparation of organometallic nucleophilic reagents and exhibits excellent functional group tolerance. Recently, breakthrough progress has been developed to the cross-electrophile coupling of C(sp^2)-X/C(sp^3)-X. The recent progress in the research of Ni-catalyzed electrophilic coupling for the construction of C(sp^2)-C(sp^2) and C(sp^2)-C(sp^3) is reviewed.

关 键 词：偶联反应 还原偶联 亲电试剂 Ni催化 

分 类 号：O621.251[理学—有机化学]