通过硝基苯与磺酰氯水相反应直接合成磺酰胺（英文）  

Direct Synthesis Sulfonamides from Nitroarenes and Sulfony Chlorides in Water

作　　者：岳会兰[1] 鲍鹏丽 王雷雷 吕晓霞[2] 杨道山 王桦[2] 魏伟 Yue Huilan;Bao Pengli;Wang Leilei;Lü Xiaoxia;Yang Daoshan;Wang Hua;Wei Wei(Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Qinghai 810008;School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165)

机构地区：[1]中国科学院藏药研究重点实验室中国科学院西北高原生物研究所,西宁810008 [2]曲阜师范大学化学与化工学院,曲阜273165

出　　处：《有机化学》2019年第2期463-468,共6页Chinese Journal of Organic Chemistry

基　　金：Project supported by the International Cooperation Project of Qinghai Province(Nos.2018-HZ-806,2017-HZ-806);the Qinghai Key Laboratory of Tibetan Medicine Research(No.2017-ZJ-Y11);the Natural Science Foundation of Shandong Province(Nos.ZR2018MB009,ZR2016JL012);the National Natural Science Foundation of China(Nos.21302109,21302110,21601106)~~

摘　　要：报道了一种简单实用的磺酰胺绿色合成方法,以硝基苯和磺酰氯为原料,铁粉为唯一还原剂,纯水作为溶剂.该反应具有反应成本低,溶剂环境友好,反应条件温和,底物适用性广的优点.A simple and practical route for construction of various sulfonamides from nitroarenes and sulfonyl chlorides with iron powder as the sole reductant in water (green solvent) under open-air conditions was developed. The protocol features low-cost, environmentally benign solvent, mild reaction conditions and wide broad substrate scope.

关 键 词：水 绿色有机合成 磺酰胺 磺酰氯 铁粉 

分 类 号：O621.25[理学—有机化学]