钯催化的肉桂基碳酸酯化合物与酰腙的烯丙基胺化反应  

Palladium Catalyzed Allylic Amination of Cinnamyl Carbonates with Acyl Hydrazones

作　　者：刘澜涛[1] 陈莹莹 张安安[1] 刘雪 张丽 白静茹 李恒[3] 毛国梁[2] Liu Lantao;Chen Yingyinga;Zhang An'an;Liu Xue;Zhang Li;Bai Jingru;Li Heng;Mao Guoliang(College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000;College of Chemistry and Chemical Engineering, Northeast Petroleum University, Daqing 163318;College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001)

机构地区：[1]商丘师范学院化学化工学院,商丘476000 [2]东北石油大学化学化工学院,大庆163318 [3]郑州大学化学与分子工程学院,郑州450001

出　　处：《有机化学》2019年第2期475-481,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21572126);河南省高校科技创新人才基金(No.14HASTIT016);河南省科技创新杰出人才(No.2018JQ0011)资助项目~~

摘　　要：烯丙基胺结构单元广泛存在于天然产物、药物和功能材料分子中,另外烯丙基胺衍生物也是一类重要的有机合成子.实现了钯催化的肉桂基碳酸酯化合物和酰腙化合物的烯丙基胺化反应,高选择性地生成了线型烯丙基胺类化合物,产率高达99%.该方法具有不需要加碱、条件温和、操作简单、底物适应范围广等优点.Allylic amines moiety exists extensively in natural products, medicines and functional materials. In addition, they are also a kind of versatile building blocks for organic synthesis. Using CH3CN as solvent, the palladium catalyzed allyl amination of cinnamyl carbonate and acylhydrazone compounds was realized under argon. The linear product was formed selectively and the up to 99% yield was obtained. The reaction has features of base free, mild reaction condition, simple operation and broad substrate scope.

关 键 词：钯催化剂 烯丙基胺化反应 肉桂基碳酸酯 

分 类 号：O621.251[理学—有机化学]