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作 者:郑晓 刘秀梅[2] 王玉梅[2] Zheng Xiao;Liu Xiumei;Wang Yumei(Department of Rheumatology and Immunology, Hebei People's Hospital, Shijiazhuang 050000, China;Department of Rheumatoid and Immunology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China)
机构地区:[1]河北省人民医院风湿免疫科,石家庄050000 [2]山西医科大学第一医院风湿免疫科,太原030001
出 处:《中华风湿病学杂志》2019年第2期113-117,共5页Chinese Journal of Rheumatology
摘 要:目的评价抗氨甲酰化蛋白(CarP)抗体对RA的诊断价值。方法计算机及手工检索国内外各数据库,包括PubMed数据库、Embase数据库、Cochrane图书馆等外文数据库,收集研究目的为抗CarP抗体对RA诊断价值的研究,时间截止2018年3月15日。排除研究人群及阈值选择不符合要求的文献,提取文献资料。采用ReviewManager5.2、Meta-disc1.4和Stata12.0软件进行文献质量评价及统计分析。结果共纳入7篇文献,异质性检验结果显示,各研究间不存在非阈值效应引起的异质性,采用固定效应模型进行Meta分析。抗CarP抗体对RA灵敏度、特异度、阳性似然比、阴性似然比分别为[45%,95%CI(43%,48%)]、[97%,95%CI(95%,98%)]、[12.65,95%CI(8.87,18.05)]、[0.56,95%CI(0.53,0.6)]。诊断比值比(DOR)为[23.97,95%CI(16.33,35.17)],受试者工作特征曲线下面积(AUC)=0.7775。结论抗CarP抗体对诊断RA特异度较高,但敏感度较差。Objective We aimed to evaluate the diagnostic value of anti-carbamylate protein antibody (anti-CarP antibody) for rheumatoid arthritis (RA).Methods All domestic and foreign database were searched by computerized and manual methods,including PubMed database,Embase database,Cochrane library.All studies about anti-CarP antibody on the diagnostic value of RA were included.The deadline of the search was March 15,2018.Studies that did not meet the population and threshold to select criteria requirements were excluded.Results Manager 5.2,Meta-disc 1.4 and Stata12.0 software were used for literature quality evaluation and statistical analysis.Results A total of 8 papers were included.The heterogeneity test showed that there was heterogeneity caused by nonthreshold effects among the studies,and random effects model was used for Meta analysis.The sensitivity,specificity,positive and negative likelihood ratios of antiCarP antibody for the diagnosis of RA were [45%,95%CI(43%,48%)]、[97%,95%CI(95%,98%)]、[12.65,95% CI (8.87,18.05)]、[0.56,95% CI (0.53,0.6)].DOR was [23.97,95% CI (16.33,35.17)] respectively,and the AUC was 0.777 5.Conclusion Anti-CarP antibody is highly specific for the diagnosis of RA,but its sensitivity is poor.
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