cAMP产生的兔股动脉舒张部分由NO介导  

The relaxation of rabbit femoral artery induced by cAMP is partly dependent on nitric oxide

作　　者：高玲[1] 徐标[1] Albert FERRO 

机构地区：[1]东南大学附属中大医院心内科,江苏南京210009 [2]Thomas Hospital,King’College

出　　处：《中国病理生理杂志》2002年第3期240-242,共3页Chinese Journal of Pathophysiology

基　　金：英国WelcomeTrust的InternationalResearchDevelopmentAwards资助 (No .0 55687/Z/ 98/Z)

摘　　要：目的 :研究cAMP产生的周围血管扩张作用是否与激活一氧化氮合酶 (NOS)有关。方法 :利用家兔股动脉恒流灌注模型 ,观察股动脉内灌注不同浓度的dbcAMP(膜渗透性cAMP)或腺苷酸环化酶的直接激动剂forskolin后灌注压的变化及NOS抑制剂L -NAME对其作用的影响。结果 :dbcAMP和forskolin均产生浓度依赖的周围血管舒张 ,NOS抑制剂L -NAME部分阻断这种作用。结论 :cAMP产生的周围血管扩张作用部分通过激活NOS实现。AIM: To determine whether vasorelaxation induced by cAMP is dependent on eNOS activation.METHODS: A constant perfusion model of rabbit femoral artery was used to observe the changes of perfusion pressure before and after intra-arterial infusing different concentrations of dbcAMP(a membrane-permeable cAMP analogue) or forskolin(a direct stimulator of adenyl cyclase) and the effects of NOS inhibitor L-NAME on their actions.RESULTS: Both dbcAMP and forskolin induced concentration-dependent relaxation of rabbit femoral artery bed and NOS inhibitor L-NAME partly inhibited this vasorelaxation.CONCLUSION: Vasorelaxation induced by cAMP is mediated partly through eNOS activation.

关 键 词：腺苷环-磷酸 一氧化氮 股动脉 兔 血管内皮细胞 CAMP 动脉舒张 

分 类 号：R543.5[医药卫生—心血管疾病]