人参皂苷-Rg_1对中性粒细胞与血小板之间粘附的影响  

Effects of ginsenoside-Rg_1 on adhesion of neutrophil to platelet

作　　者：沈志强[1] 吴蓝鸥[1] 雷伟亚[1] 陈植和[1] 刘吉开[2] 

机构地区：[1]云南省天然药物药理重点实验室,昆明医学院云南昆明650031 [2]中国科学院昆明植物研究所开放实验室,云南昆明650204

出　　处：《中草药》2002年第2期138-140,共3页Chinese Traditional and Herbal Drugs

基　　金：云南省自然科学基金资助项目 ;课题号 :98C0 66M

摘　　要：目的　探讨人参皂苷 - Rg1 对大鼠血小板与中性粒细胞之间粘附及颈动脉血栓形成的影响。方法　采用Charlton等方法评价人参皂苷 - Rg1 对电刺激大鼠颈动脉血栓形成的作用 ;应用玫瑰花结试验观察对大鼠血小板与中性粒细胞之间粘附的影响。结果　 2 5 m g/ kg人参皂苷 - Rg1 使血栓形成时间从对照组的 ( 18.7± 1.8) m in延长到( 3 6.4± 2 .1) min ( P<0 .0 5 ) ;显著降低凝血酶激活的血小板与中性粒细胞间的粘附率 ,其 IC50 为 81.2μm ol/ L。结论　人参皂苷 - Rg1 具有较强的抗血栓的作用 。Object To investigate the effects of ginsenoside Rg 1 on adhesion of neutrophil to platelet, and on carotid thrombosis in rat. Methods Charlton and Rosette test were used to evaluate the effect of ginsenoside Rg 1 on carotid thrombosis induced by electrical stimulation and to observe its effect on the adhesion of neutrophil to platelet in rat respectively. Results Ginsenoside Rg 1 25 mg/kg iv prolonged the thrombotic time from (18.7±1.8) min in control group to (36.4±2.1) min in treatment groups (P<0.05 ); the adhesion of neutrophil to thrombin stimulated platelets was inhibited significantly with IC 50 =81.2 μmol/L. Conclusion The inhibition of ginsenoside Rg 1 on the adhesion of neutrophil to platelet may contribute to its potent anti thrombotic effects.

关 键 词：人参皂苷-Rg1 中性粒细胞 血小板 粘附 血栓形成 影响 大鼠 中药 

分 类 号：R259.43[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]