2型糖尿病患者颈动脉内膜厚度及危险因素的研究  

The Study of Carotic Intima - media Thinkness and Risk Factors in Patients with Type 2 Diabetes Mellitus

作　　者：卢学勉[1] 吴锡新[1] 叶成夫[1] 

机构地区：[1]浙江省瑞安市人民医院,瑞安325200

出　　处：《中国临床医学》2002年第1期65-66,69,共3页Chinese Journal of Clinical Medicine

摘　　要：目的:探讨2型糖尿病（DM）患者颈动脉内膜厚度（IMT）及危险因素。方法:用高分辨率彩超测定102例2型DM和46例健康对照者颈总动脉（CCA）与颈内动脉（ICA）的IMT,同时测定11项可能的危险因素,用多元趋步回归分析IMT与11项危险因素间的关系。结果:DM组CCA IMT为0.864±0.358mm,ICA IMT为0.762±0.249mm;对照组CCA IMT为0.649±0.116mm,ICA IMT为0.644±0.119mm。两组间CCA IMT、ICA IMT均有显著差异（分别P<0.01,P<0.05）。2型DM患者CCA IMT主要与体重指数（BMI）、胰岛素敏感性指数（IAI）、血浆甘油三酯（TG）、空腹血糖（FBG）相关;ICAIMT主要与BMI、病程、IAI、血浆胆固醇（TC）、TG有关。结论:2型DM患者存在颈动脉内膜相对增厚。肥胖、胰岛素抵抗、高酯血症、FBG、病程可能是2型DM并发动脉粥样硬化的主要危险因素。: To investigate carotid intima - media thickness(IMT) and risk factors in patients with type 2 diabetes mellitus(DM). Methods: The IMT of common carotid artery (CCA) and internal carotid artery(ICA) was assessed by a high resolution doppler ultrasonography in 102 patients with type 2 diabetes and 46 healthy controls, and 11 probable risk factors were analysed by multiple stepwise regression. Results: The IMT of CCA and ICA were 0. 864±0. 358mm and 0. 762±0. 249mm in type 2 diabetic group, 0. 649±0. 116mm and 0. 644±0.119mm in healthy controls, respectively. There was a statistics significance between two groups (F < 0. 01, and P < 0. 05, respectively). In the diabetes group, there was independent relationship with CCA IMT to BMI, IAI [- In (FBG x FINS)], level of triglyceride in plasma, fasting blood glucose; and independent relationship with ICA IMT to BMI, duration of diabetes, IAI, level of trglyceride and cholesterol in plasma. Conclusion: The IMT of carotid is common thickened in patients with type 2 diabetes. Obesity, insulin resistance, hyperlipidemia, fasting blood glucose and duration of diabetes are important risk factors for atherosclerosis.

关 键 词：Ⅱ型糖尿病 颈动脉内膜厚率 危险因素 研究 DM IMT 

分 类 号：R587.1[医药卫生—内分泌]