特发性房颤血浆心钠素水平的变化分析  

Changes in Plasma Atrial Natriuretic Factor in Patients with Idiopathic Atrial Fibrillation

作　　者：杜同信[1] 夏小杰[2] 瞿卫[1] 王书奎[1] 孙君江[1] 

机构地区：[1]南京医科大学附属南京市第一医院放免中心,南京210006 [2]南京医科大学附属第一医院心内科,南京210006

出　　处：《标记免疫分析与临床》2002年第1期5-7,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：观察特发性房颤患者血浆心钠素水平的变化 ,探讨其发病机理。用放射免疫分析法 ,对特发性阵发性房颤患者 (A组 ) 2 1例 (其中房颤发作为A1,房颤终止为A2 ) ,特发性持续性房颤患者 (B组 ) 2 8例 ,风心病二尖瓣狭窄伴持续性房颤患者 (C组 ) 2 7例 ,阵发性室上速患者 (D组 ) 3 2例和正常对照组 (E组 ) 2 0名 ,检测血浆中心钠素、血小板计数和红细胞压积。特发性阵发性房颤发作时 ,ANF的水平明显高于A2、D、E组 (P <0 .0 1) ,B组与D、E组相比较P <0 .0 1,C组与D、E组相比较P <0 .0 1;血小板数的变化在房颤发作或终止时均没有明显差异 (P >0 .0 5 ) ,A1组红细胞压积与A2、D、E各组比较均有明显差异 (P <0 .0 1)。心钠素及红细胞压积在特发性房颤的发作过程中起着重要作用。To observe the changes in plasma atrial natriuretic factor(ANF) in patients with idiopathic atrial fibrillation and investigate its mechanism, plasma ANF, platelet count and hematocrit were detected in 21 cases with transient idiopathic atrial fibrillation (group A, A1 representing attack, while A2 termination), 28 with persistent idiopathic atrial fibrillation (group B), 27 suffered from rheumatic heart disease with mitral stenosis and persistent atrial fibrillation (group C), 32 with transient supraventricular tachycardia(group D) and 20 normal controls (group E). It was found that the level of ANF was significantly higher in patients with attacking transient idiopathic atrial fibrillation than that in group A2, D and E( P <0.01), and there was statistical difference between group B and D, E( P <0.01) and also between C and D, E( P <0.01). There was no difference in platelet count at the attack and termination of atrial fibrillation ( P >0.05), while there was significant difference in hematocrit in group Al compared with group A2, D, E( P <0.01). It suggested that ANF and hematocrit play an important role in the attack of idiopathic atrial fibrillation.

关 键 词：特发性心房纤颤 心钠素 放射免疫分析 红细胞压积 

分 类 号：R541.75[医药卫生—心血管疾病]