新型脑显像剂^(99)Tc^mN(CHDTC)_2的兔血药清除动力学及猴脑显像初步研究  

Research on Rabbit Pharmacokinetics and Monkey Brian Imaging of Novel Potential Cerebral Imaging Agent ^(99) Tc^mN(CHDTC)_2

作　　者：张燕燕[1] 张俊波[2] 王学斌[2] 赵荣生[3] 杨丽[3] 张松林[1] 王新[1] 张卫方[1] 唐志刚[2] 

机构地区：[1]北京大学第三医院核医学科,北京100083 [2]北京师范大学化学系 [3]北京大学第三医院药剂科,北京100083

出　　处：《中国医学影像技术》2002年第4期305-306,共2页Chinese Journal of Medical Imaging Technology

摘　　要：目的　对一种新型脑显像剂 99TcmN(CHDTC) 2 进行临床前兔血药清除动力学、猴脑显像研究 ,以观其有无进一步临床研究的价值。方法　将用配体交换法制备的 99TcmN (CHDTC) 2 进行兔血药清除动力学、猴脑显像研究。结果　将放化纯大于 90 %的 99TcmN(CHDTC) 2 给兔静脉注射后其清除半衰期 =8.70h ;清除率 =5 2 9.5ml/h。猴脑血流显像提示 ,注药后颅内放射性逐渐升高 ,至 1h行脑SPECT显像 ,脑灰白质显像基本清楚。提示显像剂可进入血脑屏障 ,并在脑实质有较好滞留。结论　 99TcmN(CHDTC) 2 是一种有潜力的新型脑显像剂 ,值得进行临床研究。Objective To study a novel potential cerebral imaging agent 99 Tc mN(CHDTC) 2 that would decide the value of further clinical research. Methods With prepared the complex and investigated the preclinical pharmacology in animals, kinetics of blood clearance in rabbits, cerebral imaging in a monkey were studied. Results Radiochemical purity of 99 Tc mN(CHDTC) 2 was over 90%. Kinetics of blood clearance in the rabbits showed T1/2 (β)=8.70h; Cl=529.5ml/h. Cerebral blood flow imaging of the monkey showed that blood flow was rise slowly and up to peak at one hour. SPECT showed that cerebral perfusion imaging of the monkey was clear. The results demonstrated that the agent could cross blood brain protective screen and accumulated as well as had a good retention at brain. Conclusion 99 Tc mN(CHDTC) 2 is good potential cerebral imaging agent and there is value for further clinical research.

关 键 词：放射性核素脑显像剂 动物 ^99Tc^mN(CHDTC)2 血药清除动力学 

分 类 号：R981[医药卫生—药品]