脑溢安对脑出血肝阳化风证患者血浆内皮素和一氧化氮水平的影响  

Influences of Naoyian(脑溢安) on plasma endothelin and nitric oxide level in patients with intracerebral hemorrhage of windsyndrome caused by sthenic liveryang(肝阳化风证)

作　　者：谭晓文 黎杏群[2] 程丑夫[3] 陈昌华[2] 李霞玲[2] 

机构地区：[1]湖南省湘西自治州民族中医院,湖南吉首416000 [2]中南大学湘雅医院中西医结合研究所,湖南长沙410008 [3]湖南中医学院附属第一医院,湖南长沙410007

出　　处：《中国中西医结合急救杂志》2002年第2期65-67,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：国家自然科学基金资助项目 (No.3 9670 90 7)

摘　　要：目的 :探讨脑溢安颗粒剂 (NYA)治疗脑出血的作用机制。方法 :6 5例急性脑出血患者随机分为 NYA组 (31例 )和西药组 (34例 )。分别采用 NYA或西药进行治疗 ,观察患者血浆内皮素 (ET)和一氧化氮 (NO)含量的变化及临床疗效。结果 :NYA组基本痊愈加显效率为 80 .6 % ,总有效率为 93.5 % ;西药组分别为 5 2 .9%及76 .5 %。急性期血浆 ET含量明显增高 ,NO含量明显降低 ;治疗 4周后 ,NYA组 ET和 NO基本恢复到正常范围。NYA组疗效明显优于西药组 (P<0 .0 1或 P<0 .0 5 )。结论 :NYA通过调节 ET和 NO水平来改善脑血管功能状态 。Objective:To explore the mechanism of Naoyian granule (NYA) in treatment of intracerebral hemorrhage(ICH).Methods:Sixtyfive cases with acute ICH were randomly divided into NYA group( n =31) which was treated with NYA and western medicine (WM) group ( n=34 ) which was treated with WM.The changes of plasma endothelin(ET) and nitric oxide(NO) were observed in the patients.Results:The recovery rate add obviously curative effective rate and total effective rate were 80 6%,93 5% in NYA group and 52 9%,76 5% in WM group.Plasma ET levels increased and NO levels decreased significantly in acute stage in both groups,but they returned to the normal in NYA groups after 4week treatment.The curative effects in NYA group were superior to WM group ( P <0 01 or P <0 05).Conclusions:NYA can regulate the levels of ET and NO,and improve the function of cerebral vascular,which maybe one of the mechanisms of NYA to cure ICH.

关 键 词：脑出血 肝阳化风证 脑溢安颗粒剂 内皮素 一氧化氮 中医药疗法 

分 类 号：R277.7[医药卫生—中医学]