黄芩甙对糖尿病大鼠脑缺血-再灌注损伤的影响  

Effects of baicalin on cerebral ischemiareperfusion injury in diabetic rats

作　　者：王文安[1] 蔡定芳[2] 吕传真[3] 

机构地区：[1]上海第二医科大学附属新华医院神经内科,上海200092 [2]复旦大学医学院附属华山医院中西医结合研究所,上海200040 [3]复旦大学医学院附属华山医院神经病学研究所,上海200040

出　　处：《中国中西医结合急救杂志》2002年第2期111-113,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：上海医科大学 2 0 0 0年度博士研究生毕业论文

摘　　要：目的 :观察黄芩甙对糖尿病大鼠脑缺血再灌注损伤的影响 ,并探讨其可能的作用途径。方法 :用线栓法制备糖尿病大鼠脑缺血再灌注损伤模型 ,观察不同剂量黄芩甙对缺血区脑梗死体积、髓过氧化物酶 (MPO)活性和细胞间黏附分子 1(ICAM 1) m RNA表达的影响。结果 :1黄芩甙 30 0 m g/ kg及 6 0 0 m g/ kg剂量组均较生理盐水对照组大鼠脑梗死体积显著缩小 (P均 <0 .0 5 ) ;2缺血区 MPO活性及 ICAM 1m RNA表达较生理盐水对照组显著降低 (P均 <0 .0 5 )。结论 :黄芩甙可缩小糖尿病大鼠脑缺血再灌注损伤的脑梗死体积 ,减轻白细胞浸润程度 ,其保护作用是通过抗炎途径来实现的 ,并与抑制 ICAM 1的表达有关。Objective:To observe the effects of baicalin on cerebral ischemiareperfusion injury in diabetic rats and to preliminarily explore the mechanisms of its action.Methods:Using intravascular thread tying method cerebral ischemiareperfusion rats model with diabetes mellitus were established.The effects of baicalin in different dosage groups on brain infarction size,myeloperoxidase (MPO) activity,and intracellular adhesion molecule1(ICAM1) mRNA expression were evaluated.Results:Baicalin markedly reduced infarction volume,MPO levels and ICAM1mRNA expression at the dosage group of 300 mg/kg and 600 mg/kg(all P <0.05).Conclusions:Baicalin can attenuate cerebral ischemiareperfusion injury and inflammatory response in ischemic region in diabetic rats.The antiinflammation activity of baicalin might work through inhibition of ICAM1 expression.

关 键 词：黄芩甙 糖尿病 脑缺血-再灌注 白细胞 细胞间黏附分子-1 髓过氧化物酶 

分 类 号：R587.1[医药卫生—内分泌]