马拉色菌属RAPD基因分型与相关疾病的关系  

The Relationship of RAPD Genotypes of Malassezia and Related Diseases

作　　者：郑义[1] 王玮臻[1] 刘梦琼[2] 夏清[1] 段逸群[1] 

机构地区：[1]武汉市第一医院皮肤科,武汉430022 [2]海南省人民医院检验科,海口570311

出　　处：《武汉大学学报（医学版）》2002年第1期56-58,68,共4页Medical Journal of Wuhan University

基　　金：中华医学会皮肤科分会科研基金资助项目 (112 )

摘　　要：目的 :探讨马拉色菌属在临床疾病中的意义。方法 :利用RAPD对临床分离株进行基因分型 ,建立马拉色菌属带型关系树状图 ,分析与相关疾病的对应关系。结果 :临床标本可分成 6类 ,其中 5类可进一步分为亚类。各类与疾病无明显的对应关系 ,但可得到具有临床意义的结果。结论 :RAPD作为研究马拉色菌属基因多态性的工具 。Objective:To study the meaning of Malassezia in clinical diseases. Methods:clinical isolates using RAPD (random amplified polymorphic DNA)were genotyped and established DNA banding pattern dendrogram to analyze the corresponding relationship between them and related diseases. Results:The result showed that all clinical samples were divided into 6 groups, five of which were further devided into subgroups. Significantly clinical value results were obtained in spite of no obvious corresponding relationships among them. Conclusion: RAPD can be used to study gene polymorphic of Malassezia and epidemiologic investigation for related diseases.

关 键 词：马拉色霉菌属 聚合酶链反应 基因分型 皮肤真菌病 病因9学 RAPD基因 

分 类 号：R756[医药卫生—皮肤病学与性病学] R379.9[医药卫生—临床医学]