原因不明不孕患者血清抗精子抗体、抗子宫内膜抗体和抗心磷脂抗体测定  

Determination of antisperm antibody, antiendometrial antibody, and anti-cardiolipin antibody in patients with unexplained infertility

作　　者：贾莉婷[1] 马奎[1] 刘东峰[1] 唐琳[2] 任芬若[2] 

机构地区：[1]郑州大学第三附属医院免疫室,郑州450052 [2]郑州大学第三附属医院妇产科,郑州450052

出　　处：《郑州大学学报（医学版）》2002年第1期3-5,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省科技攻关基金资助项目961200437

摘　　要：目的:探讨免疫因素抗精子抗体(AsAb)、抗子宫内膜抗体(EmAb)和抗心磷脂抗体(ACL)在原因不明不孕患者发病中所起的作用。方法:采用凝集试验和ELISA方法对537例原因不明不孕患者和40名正常对照组的血清 AsAb、EmAb和 ACL进行检测。结果:①不孕组 AsAb阳性率为 24．02%,明显高于正常对照组的 5．00%(P＜0．05);②不孕组 EmAb总阳性率为49．53%,其中IgG阳性率11．73%,IgM 32．40%,2者同时阳性 5．40%,均明显高于正常对照组(P＜0．05);③不孕组ACL总阳性率为 51．14%,其中 IgG阳性率 8．33%,IgM 32．20%,2者同时阳性10．61%,均明显高于正常对照组(P＜0．05)。结论:AsAb、EmAb和ACL在不孕症的发病中均起着不可忽视的作用。Aim:To study the role of immune factors: antisperm antibody(AsAb), antiendometrial antibody(EmAb), and an-ticardiolipin antibody ( ACL) in patients with unexplained infertility. Methods: Serum AsAb was measured by agglutination test, serum EmAb and ACL were measured by ELISA for 537 women with unexplained infertility (study group) and 40 normal women (control group). Results:①The positivity rate of serum AsAb in study group was significantly higher than that in control(24.02% VS 5.00 % , P < 0.05). ②The total positivity rate of EmAb in study group was 49.53 % (IgG, IgM, and IgG + IgM were 11.73 % , 32.40% and 5.40% respectively), which was significantly higher than that of control group ( P < 0.05) .③The total positivity rate of ACL in study group was 51.14% (8.33% for IgG,32.20% for IgM and 10.61% for IgG+IgM), which was significantly higher than that of control group ( P < 0.05). Conclusion: AsAb, EmAb and ACL play an important role in the process of unexplained infertility.

关 键 词：不孕症 抗精子抗体 抗子宫内膜抗体 抗心磷脂肪体 AoAb EMAB ACL 

分 类 号：R711.6[医药卫生—妇产科学]