水杨酸羟基磷酰化产物的合成  

Study on the phosphorylating reaction by salicylic acid and DIPPH

作　　者：郭蕾[1] 陈晓岚[1] 卢建莎[1] 赵清治[1] 朱卫民[1] 

机构地区：[1]郑州大学基础医学院有机化学教研室,郑州450052

出　　处：《郑州大学学报（医学版）》2002年第1期56-58,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:研究水杨酸羟基磷酰化产物的合成。方法:冰盐浴条件下,二异丙基亚磷酸酯(DIPPH)和四氯化碳混合液滴加到水杨酸、三乙胺、乙醇的混合液中,水杨酸和DIPPH发生磷酰化反应。结果与结论:在该条件下水杨酸可以和DIPPH发生磷酰化反应,生成水杨酸羟基磷酰化产物。Aim: To study the reaction of salicylic acid and phosphorylating agent-DIPPH.Methods:The reaction took place by dropping the solution of DIPPH and tetrachloromethane into the mixed solution of salicylic acid,triethylamine,andethanol. Results and Conclusion: The phosphorylating reaction could happen under the condition mentioned between salicylic acid and phosphorylating agent-DIPPH. The target product could be determined by NMR.

关 键 词：二异丙基亚磷酸酯 水杨酸 羟基磷酰化 合成 

分 类 号：O627.51[理学—有机化学]