妇炎消冲剂抗炎、镇痛的实验研究  

Experimental research on analgesia and anti-inflammation of Fuyanxiao-chongji

作　　者：李晓雯 刘清云[1] 陈辉[1] 宋国英[1] 徐朝阳[1] 韩萍[2] 陈宗德[3] 于蕾 

机构地区：[1]郑州大学基础医学院细胞生物学与医学遗传学教研室,郑州450052 [2]郑州大学公共卫生学院营养与食品卫生学教研室,郑州450052 [3]郑州大学基础医学院微生物学与医学免疫学教研室,郑州450052 [4]许昌市第二人民医院妇产科,许昌461000

出　　处：《郑州大学学报（医学版）》2002年第1期67-70,共4页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨妇炎消冲剂抗炎、镇痛的药效作用。方法;小鼠(或大鼠)随机分组:空白对照组给1Og/1羧甲基纤维素,阳性对照组给阿司匹林(0．2 g/kg),高剂量组、中剂量组和低剂量组分别按 20 g/kg、10 g/kg、5 g/kg 3个剂量给妇炎消冲剂,各组n＝1O。用巴豆油致小鼠耳肿胀、塑料管致大鼠子宫肿胀、棉球肉芽肿等方法观察妇炎消冲剂的抗炎作用;扭体法、热板法观察妇炎消冲剂的镇痛作用,并测定致炎大鼠子宫前列腺素含量。结果:与空白对照组比较,各高剂量组(20 g/kg)和塑料管致大鼠子宫肿胀法、扭体法的中剂量组差异有显著性(P＜0．O1);巴豆油致小鼠耳肿胀、棉球肉芽肿、热板法等中剂量组差异有显著性(P＜0．05);大鼠子宫前列腺素高、中、低剂量组差异均有显著性(P＜0．01)。 结论:妇炎消冲剂具有显著抑制炎性组织增生、消除肿胀、抗炎镇痛的作用。Aim: To observe the pharmacological effect of Fuyanxiaochongji on endometriosis. Methods: Fifty rats (or mice) were randomly allocated into experiment and control groups. Blank control group was treated with the same volume of 1 % CM-cellulose, positive control group was treated with aspirin(0. 2g/kg), experiment groups were treated with high dosage of Fuyanxiaochongji (20g/kg), moderate dosage (10g/kg), and low dosage (5g/kg), respectively. We used the methods that crotonic oil induced rat s ear swelling, plastic pipe induced rat's uterus swelling and having cotton ball granuloma to observe the anti-infalma-tion effect of Fuyanxiaochongji and the methods of twisting body and heat plate to observe the analgesic effect of Fuyanxiaochongji then the mechanism of analgesia was studied through observing the change of contents of prostatitis induced by Fuyanxiaochongji. Results: Compared to the blank control group, every high dosage group and all the moderate dosage groups of plastic pipe inducing rats' uterus swelling and twisting body all have extremely significant difference( P < 0.01) ;all the moderate dosage groups of crotonic oil inducing rats' ear swelling, cotton ball granuloma, heat plate had significant difference ( P < 0.05); all the high, moderate, low dosage groups of prostatitis levels in rat' s uterus had extremely significant differences ( P < 0. 01). Conclusions: Fuyanxiaochongji has the effects that significantly restrain inflammatory tissue s proliferation and eliminate swelling and also have analgesic, anti-inlarnmatory effects.

关 键 词：妇炎消冲剂 抗炎 镇痛 实验研究 中药 

分 类 号：R285.5[医药卫生—中药学]