电灼联合干扰素治疗尖锐湿疣患者血清sIL-2R变化  

Changes of the sIL-2R levels in the patients with condyloma acuminatum fulguration combining interferon α-2a therapy

作　　者：李秋涛[1] 杨宇辉 

机构地区：[1]郑州铁路局中心医院皮肤科,郑州450052 [2]洛阳轴承集团公司总医院皮肤科,洛阳471003

出　　处：《郑州大学学报（医学版）》2002年第1期80-81,共2页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨尖锐湿疣(CA)患者的细胞免疫功能。方法:尖锐湿疣患者36例,随机分为 A、B2组。A组21例患者在电灼术后给予干扰素肌内注射 10 d,B组 15例仅给予电灼术治疗,另选正常对照组 12例。应用 ELISA法测定治疗前、后 10 d及正常对照组血清可溶性白介素 2受体(sIL-2R)水平。结果:2组患者血清中sIL-2R水平均高于正常对照组(P＜0.01)。A组患者血清sIL-2R水平治疗后较治疗前显著降低(P＜0.01);B组患者治疗前后差异无显著性(P＞0.05)。结论:提示尖锐湿疣患者在发病阶段细胞免疫功能可能是下降的,干扰素可部恢复尖锐湿疣患者的细胞免疫功能。Aim: To study the cellular immunity function of patients with CA. Methods: A total of 36 cases of CA were divided into group A and group B randomly. Group A (21 patients) was received interferon after fulguration. Group B (15 patients) was only received fulguration. Meanwhile, 12 healthy participants were taken as normal controls. ELISA method was used to detect the sIL-2R levels of CA patients before and after treatment and normal controls. Results: Levels of sIL-2R of group A and B were all significantly higher than those of normal controls ( P < 0.01). The sIL-2R level in group A was significantly lower after treat-ment( P < 0.01). There was no significant difference in group B before and after the treatment (P > 0.05). Conclusions: This study suggests that CA patients' cellular immunity function might decrease during the course of disease. Interferon therapy might have some significant effects on the improvement of the cellular immunity function.

关 键 词：尖锐湿疣 电灼 干扰素 SIL-2R 联合治疗 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]