丹贝异黄酮对肿瘤的抑制效应  

Effect of tempe isoflavones on tumor

作　　者：徐德平[1] 高霞[1] 江汉湖[1] 翟成凯[2] 

机构地区：[1]南京农业大学食品科技学院,江苏南京210095 [2]东南大学医学院,江苏南京210009

出　　处：《南京农业大学学报》2002年第1期97-101,共5页Journal of Nanjing Agricultural University

基　　金：国家自然科学基金资助项目 (3 9470 610 )

摘　　要：用丹贝异黄酮提取物对携S 180肿瘤的BALB/C小鼠作用 ,结果丹贝异黄酮提取物高剂量时有 30 9%的抑瘤率 ,并能显著提高荷瘤小鼠的胞腺指数、脾指数和巨噬细胞的吞噬作用。以分离纯化的大豆和丹贝异黄酮的 5个单体染料木素糖苷、大豆苷元糖苷、黄豆黄素苷元、染料木素苷元、大豆苷元 (genistin、daidzin、glycitein、genistein、daidzein)分别作用于乳腺癌MCF 7细胞株、子宫癌HeLa细胞株和卵巢癌HO 8910细胞株 ,研究各单体对各种癌细胞株的抑制率和IC50值。结果显示 ,染料木素在 10 -4mol·L-1时对 3株癌细胞均有较高的抑制率 ,大豆苷元在 10 -4mol·L-1时对卵巢癌HO 8910细胞株有较强的抑制效果。丹贝异黄酮比大豆异黄酮有更强的抑制肿瘤的作用 ,其中染料木素有更广泛、更强的活性 。Effects of tempe isoflavones on BALB/C mice carried S?180 were studied.The high dose of tempe isoflavones inhibited tumor growth with the inhibitiary rate in 30 9% and significantly enhenced the thymus index and activity of macrophage(mφ).Three cancer cell lines including MCF?7,HeLa,HO?8910 were treated by genistein,daidzein,glycitein,genistin and daidzin,respectively.Genistein significantly inhibited three kinds of tumor cell line and daidzein had effect on HO?8910 cell line.Tempe isoflavones had stronger antitumor activity than soybean isoflavones.Gensitein had the most extensive and strongest antitumor activity and isoflavone glucoside had no antitumor activity.

关 键 词：丹贝 异黄酮 抗肿瘤 提取物 抑制效应 

分 类 号：R282.71[医药卫生—中药学] R284.2[医药卫生—中医学]