羧乙基锗倍半氧化物对大鼠肺缺血再灌注损伤的保护作用  

THE PROTECTIVE EFFECTS OF CARBOXYETHYI-GERMANIUM SESQUIOXIDE ON LUNG ISCHEMIA-REPERFUSION INJURY IN RATS

作　　者：王洋[1] 王善政[1] 胡雪梅[2] 

机构地区：[1]山东大学齐鲁医院胸外科,济南250012 [2]山东大学校医院

出　　处：《青岛大学医学院学报》2002年第1期40-42,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的　观察羧乙基锗倍半氧化物 (CGS)对大鼠实验性肺缺血再灌注损伤的影响。②方法　采用Wistar大鼠原位肺缺血再灌注损伤模型 ,测定再灌注后左肺动脉压、左肺湿干质量比值 ,肺组织中丙二醛 (MDA)含量、超氧化物歧化酶 (SOD)及ATPase活性。③结果　同对照组比较 ,预防性静注CGS(5 0mg/kg体质量 )后 ,可显著降低再灌注肺组织中MDA和左肺动脉压及肺湿干质量比值 (F =3.85～ 6 .37,q=4 .2 1～ 8.98,P <0 .0 5 ,0 .0 1) ;明显提高肺组织中SOD及ATPase活性 (F =4 .39,5 .86 ,q =8.6 4 ,10 .2 1,P <0 .0 5 ,0 .0 1)。Objective\ To observe the effects of carboxyethi germanium sesquioxide (CGS) on lung ischemia reperfusion. Methods\ The experimental model was established in rats by ligating the left lung hilum for 30 minutes followed by reperfusion for 60 minutes. The left pulmonary artery pressure,left lung m w/m d ,level of MDA, activity of SOD and ATPase were measured. Results \ Compared with the controls, intravenous injection of CGS (50 mg/kg) significantly decreased the level of MDA and m w/m d , improved activity of SOD and ATPase in lung of rats( F=3.85-6.37,q=4.21-10.21, P <0.05,0.01).\ Conclusion\ CGS might have a protective effect on the damage of lung ischemia reperfusion in rats.

关 键 词：锗 肺缺血 再灌注 丙二醛 超氧化物歧化酶 

分 类 号：R965[医药卫生—药理学]