慢性乙型肝炎病人可溶性白细胞介素2受体的检测  

THE DETECTION OF SOLUBLE INTERLEUKIN-2 IN PATIENTS WITH CHRONIC HEPATITIS B

作　　者：王启娟[1] 万谟彬[2] 李成忠[2] 张迁[2] 刘建涌[2] 陈姬秀[2] 

机构地区：[1]中国人民解放军第401医院感染科,青岛266071 [2]第二军医大学长海医院感染科

出　　处：《青岛大学医学院学报》2002年第1期62-63,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的　探讨血清中可溶性白细胞介素 2受体 (sIL 2R)在慢性乙型肝炎发病机制中的作用及临床应用价值。②方法　采用双抗体夹心酶联免疫法检测 2 81例慢性乙型肝炎病人和 16例脂肪肝病人 (其中 2 6 5例慢性乙型肝炎和 16例脂肪肝病人做了肝穿刺活组织检查 ,16例慢性重型乙型肝炎病人未做肝穿刺活组织检查 )的血清sIL 2R水平。③结果　sIL 2R水平随着肝脏组织炎症及肝纤维化的进展而增高 ,各组与对照组比较有显著性差异(F =6 .0 9,4 .0 6 ,q =2 .35～ 7.19,P <0 .0 5 ,0 .0 0 1)。④结论　慢性乙型肝炎病人血清sIL 2R的变化可作为判定肝组织炎症及纤维化病变程度的指标之一 ,可对预后作出有价值的判断 。Objective\ To study the effect of serum soluble interleukin 2 receptor(sIL 2R) in the development of chronic hepatitis B(CHB) and its value for clinical application. \ Methods\ Serum sIL 2R was detected in 297 patients with monoclonal and polyclonal antibody ELISA, in which, needle liver biopsy was done in 265 patients for CHB and 16 for fatty liver, and 16 with severe CHB were exemption from the biopsy.\ Results\ The increase of sIL 2R level was associated with the development of hepatic inflammation and fibrosis. The differences were significant as compared with the control( F=6.09, 4.06, q=2.35-7.19, P < 0.05 ,0.001).\ Conclusion\ The serum sIL 2R of patients with CBH is one of useful markers for determining the degree of inflammation and fibrosis of the liver and providing an evidence for therapy as well as an evaluation of prognosis for CHB patient.

关 键 词：病毒性肝炎 活组织检查 受体 白细胞介素2 

分 类 号：R512.62[医药卫生—内科学]