肺炎支原体特异性IgA抗体检测的临床意义  

Clinical significance of the determination of isotype specific IgA antibody against mycoplasma pneumoniae

作　　者：曹兰芳[1] 陆伟蓉[1] 毛海英[1] 夏敏[1] 徐凌云[1] 顾梯成[1] 

机构地区：[1]上海第二医科大学附属仁济医院儿科上海第二医科大学附属仁济医院过敏诊治中心,上海200001

出　　处：《临床儿科杂志》2002年第3期134-136,共3页Journal of Clinical Pediatrics

基　　金：上海市科委项目 (编号 :004119050)

摘　　要：为探讨肺炎支原体特异性IgA抗体在肺炎支原体感染患儿中的临床意义 ,采用酶联免疫吸附试验 (ELISA)对296例临床疑诊肺炎支原体肺炎患儿进行特异性抗体MP -IgA检测 ,并与同时采用日本富士明胶颗粒凝集法测定的特异性MP -IgM抗体比较 ;对其中57例进行了为时2月～5.5月随访。结果显示 ,MP -IgA与MP -IgM测定结果高度一致 ,其阳性率随MP -IgM滴度上升及病程延长而增加 ,而MP -IgM滴度大部分在感染后3个月左右下降 ,部分持续时间较久 ;在呼吸道感染患儿中 ,MP -IgA阳性率增加明显 ,而MP -IgM下降速度显著减慢。结果表明 :MP特异抗体IgA测定对提高MP感染诊断的敏感性。ToexploretheclinicalsignificanceofisotypespecificIgAantibody againstmycoplasmapneumoniaein childrenwithmycoplasmapneumoniaeinfections,MP -IgAwasmeasuredwithELISAmethodaswellasspecificIgMan tibodyagainstmycoplasmapneumoniae(MP -IgM)wassimultaneouslycarriedoutwithpelletagglutinationassayascom parisonin296childrenprescriblydiagnosedasmycoplasmapneumoniaduetomycoplasmapneumoniae.57casesofthem wereprospectivelyfollowedupfor2～5.5months.TheresultsclearlyshowedthatthepositiverateofMP -IgAwasfound tocoincidedwiththeheightofMP -IgMtitre.And,theincreaseofpossitiverateofMP -IgAwasaccompaniedwiththe elevatedMP -IgMtitreandtheprolongeddiseasecourse.MP -IgMtitrecouldgraduallydecreasetonormallevelinnearly 3monthsinmostcasesexceptthatthistitreinasmallpartofcasesmaybesustainedlonger.Furthermore,thepositiverate ofMP -IgAwasobviouslyelevatedaswellasMP -IgMtitrealsoappearedmuchhigherinchildrenwithrespiratorytract infectionduetomycoplasmapneumoniae.Hence,itissuggestedthatthedeterminationofMP -IgAisofsignificantim portanceasaspecificandsensitiveindexin the clinicaldiagnosis of mycoplasma pneumoniae infections in children.

关 键 词：肺炎 肺炎支原体 特异性IgA抗体 特异性IGM抗体 检测 诊断 

分 类 号：R446.62[医药卫生—诊断学]