儿童哮喘外周血嗜酸细胞阳离子蛋白、内皮素和肿瘤坏死因子-α的水平变化及临床意义  

Detection of peripheral eosinophil cation protein,endothelin and tumour necrostic factor-α levels and its clinical significance in children with bronchial asthma

作　　者：张云峰[1] 马青山[1] 成焕吉[1] 鲁继荣[1] 付文永[1] 

机构地区：[1]吉林大学附属第一临床医学院儿科,吉林长春130021

出　　处：《临床儿科杂志》2002年第3期150-151,166,共3页Journal of Clinical Pediatrics

摘　　要：为探讨细胞因子及炎性介质在哮喘病发病中的作用 ,采用放免方法对69例哮喘患儿外周血发作期和缓解期血清嗜酸细胞阳离子蛋白 (ECP)、血管内皮素 (ET)及肿瘤坏死因子 (TNF_α)的水平进行了检测。结果发现ECP、ET及TNF_α发作期水平较缓解期和正常对照组明显增高 (P均<0.01) ;缓解期水平有明显下降 ,但仍然高于正常对照组。提示检测哮喘患儿外周血ECP、ET及TNF_α水平 ,对于判断哮喘病期、严重程度。To explore the possible role of different cytokines and inflammatory media in the pathogenesis of bronchial asthma in children,the levels of eosinophil cation protein(ECP),endothelin (ET) and tumour necrostic factor_α(TNF_α) in peripheral blood were investigated in 69 children with asthma separately during attack and recovery stages.The results obtained showed that all of these 3 data in attack stage were very significantly higher than those in recovery stage and normal control group.Moreover,although there was an evident decrease in all these data in recovery stage,the levels of them remained higher than those of normal control.Finally,it is,then,concluded that the detection of ECP,ET and TNF_α levels in peripheral blood might be an important guiding index for judging disease stages,severity,prognosis and even prevention and treatment of childhood asthma.

关 键 词：哮喘 嗜酸细胞阳离子蛋白 血管内皮素 肿瘤坏死因子 儿童 

分 类 号：R725.6[医药卫生—儿科]