广州地区382名健康学龄儿童脉冲振荡肺功能的测定  

Determination of impulse oscillation (IOS) respiratory parameters in 382 healthy school-age children in Guangzhou area

作　　者：郑劲平[1] 李敏然[1] 安嘉颖[1] 罗锭芬[1] 彭淑梅[2] 

机构地区：[1]广州医学院附属第一医院广州呼吸疾病研究所肺功能室,510120 [2]广东省妇幼保健院肺功能室

出　　处：《中华儿科杂志》2002年第4期225-229,共5页Chinese Journal of Pediatrics

基　　金：广东省卫生厅科学基金(A1997241)

摘　　要：目的　探讨儿童脉冲振荡肺功能技术 (IOS)的特点 ,建立国内儿童的正常参考值。方法对 382例 6～ 14岁正常儿童 (男性 196例 ,女性 186例 ) ,采用德国Jaeger公司生产的MasterscreenIOS肺功能仪 ,参考欧洲呼吸学会标准测定呼吸总阻抗 (Zrs)、不同振荡频率 (5Hz～ 35Hz)的粘性阻抗 (Rrs)及电抗 (Xrs)、响应频率 (Fres)等 2 0个指标 ,并对各实测指标作多元逐步线性回归及曲线回归 ,得出预计方程式。以实测数据与试验所得方程的预计值及Lechtenboerger方程式预计值进行相关系数的配对比较。结果　Zrs、Rrs与儿童生长 (身高及年龄 )呈负相关 [Zrs(男 ) =- 1 0 4 8+2 34 398/身高 ,r =-0 839,P <0 0 0 1;Zrs(女 ) =- 1 14 8+2 4 4 36 6 /身高 ,r=- 0 812 ,P <0 0 0 1];而Xrs则与儿童生长呈正相关 ,且变异减少。振荡频率 5Hz与 2 0Hz下的气道阻力之差 (R5-R2 0 )与儿童身高呈负相关 ,R5-R2 0 (男 ) =0 74 9- 0 0 0 4 3×身高 ,r=- 0 6 86 ,P <0 0 0 1;R5-R2 0 (女 ) =0 85 1- 0 0 0 5 1×身高 ,r=-0 6 2 7,P <0 0 0 1。多数IOS参数与身高的关系最为密切 ,年龄次之 ,体重的影响相对较少 ;建立了各IOS呼吸阻抗主要指标的多元回归方程式。IOS各实测值与所得方程预计值的相关系数均大?Impulse oscillation technique (IOS) provides a simple, rapid and non invasive method for estimating multipe respiratory physiological parmeters such as respiratory impedance, resistance, and reactance. IOS has been available and being clinically practiced more and more in China. The results of the tests cannot be interpreted appropriately without reference values, which should be based on the same ethnic population. However, there are no such references available for Chinese children until now. Objective To characterize the passive respiratory mechanics and its variability with growth, and to establish the predicted equations for Chinese children Methods A survey was conducted on 392 healthy Chinese school children (196 boys, 186 girls) aged 6 to 14 years from August 1998 to March 1999 Respiratory impedance (Zrs), respiratory resistance (Rrs) and reactance (Xrs) at 5, 10, 15, 20, 25, 30 and 35 Hz, resonant frequency (Fres), central and peripheral resistance (Rc, Rp) were measured with Jaeger Masterscreen IOS instrument Measurements were carried out during spontaneous breathing and met the recommendations made by European Respiratory Society Stepwise multiple regressions and non linear regressions were carried out with SPSS 9 0 for Windows statistical software to identify the best predictors of IOS parameters using standing height, weight, age and gender as potential determinants The difference of resistance at the frequency between 5 Hz and 20 Hz (R 5-R 20 ) was considered as frequency dependence of resistance The correlation coefficients between measured data and predicted values derived from our regressions were compared with that from Lechtenboerger′s regressions Results There was negative correlation between all parameters and height as well as age except for reactance, Zrs(Boys)= -1 048+234 398/height, r =-0 839, P <0 001; Zrs(Girls)=-1 148+244 366/ height, r =-0 812, P <0 001; negative relationships were found between R 5-R 20 and growth in both boys an

关 键 词：气道阻力 呼吸功能试验 儿童 参考值 

分 类 号：R560.4[医药卫生—呼吸系统]