激光汽化活体生物组织的传热过程分析  

Theoretical Analysis on Heat Transfer Process in Living Tissues Subjected to Continuous Laser Ablation

作　　者：李和杰[1] 刘静[2] 张学学[1] 

机构地区：[1]清华大学热能工程系,北京100084 [2]中国科学院理化技术研究所低温中心,北京100080

出　　处：《航天医学与医学工程》2002年第2期103-107,共5页Space Medicine & Medical Engineering

基　　金：国家自然科学基金;清华大学机械工程学院基础研究基金与中国科学际百人计划合作项目 (5 0 1760 5 3 )

摘　　要：目的研究激光汽化生物活体组织的传热过程及其影响因素。方法基于血液灌注率温度依赖型Pennes生物传热方程 ,建立激光与生物活体组织热相互作用的一般模型 ,研究组织表面发生汽化相变、中间组织出现热凝结、内层组织发生温升的过程。由此探讨组织中的激光传输特性 ,以及血液灌注率和边界冷却等因素的影响情况。结果通过数值计算 ,得出活体组织表面汽化速度及内部温度分布。研究表明 ,活体组织对不同激光的吸收能力、血液灌注率与边界冷却条件对组织汽化速度、组织凝结过程及温度分布有显著影响。结论该模型可用于预测激光汽化蚀除组织的过程 ,分析结果对激光临床应用具有理论指导意义。Objective To analyse heat transfer process in living tissues subjected to continuous laser ablation. Method A model for characterizing laser induced thermal coagulation and ablation in living tissues was presented basing on Pennes , bio heat equation with temperature dependent blood perfusion. The influences of light absorption, blood perfusion and surface cooling on the heat transfer process were analyzed. Result Ablation velocity, coagulation depth and temperature profiles in living tissue were numerically obtained. It was found that effects of different laser absorptance, blood perfusion and cooling condition on heat transfer were significant. Conclusion The transient heat transfer behavior in living tissues under laser ablation can be predicted by the present model. This study is beneficial for the clinical practices of laser surgery on human body.

关 键 词：激光医学 热相互作用 血流灌注 汽化 凝结 生物传热 

分 类 号：Q631[生物学—生物物理学]