宫颈阴道分泌物中的胰岛素样生长因子结合蛋白-1在早产预测中的价值  

The Value of Cervicovaginal Insulin Like Growth Factor Binding Protein-1 in the Prediction of Preterm Labor

作　　者：张新玲[1] 李小毛[1] 郑荣琴[1] 杨越波[1] 侯红瑛[1] 

机构地区：[1]中山医科大学附属第三医院,广东广州510630

出　　处：《实用妇产科杂志》2002年第2期107-108,共2页Journal of Practical Obstetrics and Gynecology

基　　金：广东省科委科研基金资助课题 ( 1998-0 4)

摘　　要：目的 :探讨宫颈阴道分泌物中高磷酸化的胰岛素样生长因子结合蛋白 - 1(IGFBP- 1)在早产预测中的价值。方法 :应用免疫层析法检测 10 8例孕妇宫颈阴道分泌物中高磷酸化 IGFBP- 1的含量。结果 :先兆早产组、正常妊娠组IGFBP- 1的阳性率分别为 48.2 % (2 7/ 5 6 )和 7.7% (4 / 5 2 ) ,两组结果相比较 ,差异有统计学意义 (P<0 .0 5 )。结论 :宫颈阴道分泌物中的胰岛素样生长因子结合蛋白 -Objectives:To study the value of the phosphorylated isoforms of insulin like growth factor binding protein-1(IGFBP-1) in cervicovaginal secretions in prediction of preterm labor.Methods: Phosphorylated isoforms of IGFBP-1 in cervicovaginal cecretions of 108 pregnant women was measured by a immunochromatography methods.Results: The positive rate of IGFBP-1 in threatened preterm labor group and normal group was respectively 48.2%(27/56)and 7.7%(4/52).There are statistically significant differences between the two groups(P<0.05).Conclusions: Phosphorylated isoforms of IGFBP-1 can be used as the objective indicators for prediction of preterm labor.

关 键 词：胰岛素样生长因子结合蛋白 分娩 早产 宫颈阴道分泌物 预测 

分 类 号：R714.21[医药卫生—妇产科学]