新清肝饮对急性酒精损伤小鼠胃粘膜ET、NO的影响  

Effects of XinQingGanYin on Endothelin and Nitric Oxide in Gastric Mucosa of Acute Alcoholic Injury in Mice

作　　者：李佃贵[1] 扈国杰[1] 李振彬[2] 栗世方[3] 

机构地区：[1]河北省中医药研究院,石家庄050031 [2]白求恩国际和平医院 [3]山东大学齐鲁医院

出　　处：《中国中医药信息杂志》2002年第3期31-32,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：河北省科学技术研究与发展计划资助课题(№:99276154D)

摘　　要：目的:观察新清肝饮对急性酒精损伤小鼠胃粘膜ET、NO的影响。方法:采用小鼠急性酒精损伤模型,测定小鼠胃粘膜ET、NO的含量。结果:急性酒精损伤小鼠胃粘膜ET含量升高;急性酒精损伤小鼠胃粘膜NO含量无明显变化;新清肝饮可降低急性酒精损伤小鼠胃粘膜ET含量,而对NO含量无明显影响。结论:新清肝饮对急性酒精损伤小鼠胃粘膜ET具有调节作用,提示新清肝饮对急性酒精损伤胃粘膜具有保护作用。Objective: Study the effects of XinQingGanYin(XQGY) on endothelin(ET) and nitric oxide(NO) of gastric mucosa in acute alcohol injured mice. Methods: The acute injured gastric musoca model was established by alcohol. The levels of ET, NO were determined after 6 hours. Results: The level of ET in gastric musoca increased significantly. The change of NO was not obvious. The level of ET could be reduced by XQGY and the level of NO did not change. Conclusions: XQGY may protect gastric musoca in acute alcohol injured mice by decreasing the level of ET in gastric tissue. That provides an experimental evidence in GanWeiTongZhi theory of TCM.

关 键 词：新清肝饮 胃粘膜损伤 乙醇 内皮素 一氧化氮 小鼠 治疗 

分 类 号：R259.73[医药卫生—中西医结合]