充血性心力衰竭病人血凝指标检测的意义  

Change and its meaning of clotting index in patients with congestive heart failure

作　　者：赵金晶[1] 傅鑫[1] 张湘兰[1] 

机构地区：[1]沈阳医学院附属二院心内科,辽宁沈阳市110002

出　　处：《心血管康复医学杂志》2002年第2期118-120,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的 :观察充血性心力衰竭 (CHF)病人各项血凝指标的变化 ,探讨其临床意义。方法 :用酶联免疫吸附双抗体夹心法测定 47例 CHF病人及 2 0例正常人血浆 Von Willebrand因子 (v WF)、血小板 α-颗粒膜蛋白 (GMP-140 )、血浆 D-二聚体 (D- Dimer)水平。结果 :CHF病人体内上述指标与对照组比较有显著差异 (P<0 .0 5 ) ,并随心力衰竭加重而增加 ,伴房颤病人上述指标变化更显著。结论 :充血性心力衰竭病人 ,特别是心衰严重 ,伴有房颤的病人的血液处于高凝状态。Objective:To explore the change and its meaning of plasma vWF factor,GMP-140,D-Dimer levels in patients with congestive heart failure(CHF).Methods:The levels of plasma vWF factor,GMP-140,D-Dimer were estimated by double-antibody system ELISA in 47 patients with CHF and 20 normal controls.Results:There were significant difference(P<0.05) between CHF patients and controls in levels of vWF factor,GMP-140,D-Dimer.Conclusion:Hypercoagulable state exists in patients with CHF,especially in patient with severe CHF and atrial fibrillation.

关 键 词：充血性心力衰竭 血小板Α-颗粒膜蛋白 血浆Von Willerand因子 血浆D-二受体 酶联免疫吸附双抗体夹心法 CHF 

分 类 号：R541.61[医药卫生—心血管疾病]