地塞米松诱发的大鼠胰岛素抵抗模型  

INSULIN RESISTANCE MODEL INDUCED BY DEXAMETHASONE IN RATS

作　　者：张芳林[1,2] 刘小莺[1] 林益川[1] 张闿珍[1] 

机构地区：[1]福建医科大学附属协和医院,福建内分泌研究所,福建福州350001 [2]上海第二医科大学附属瑞金医院,上海市内分泌研究所

出　　处：《中国应用生理学杂志》2002年第1期98-100,共3页Chinese Journal of Applied Physiology

基　　金：福建省卫生厅青年基金资助课题 (Q98 1 19)

摘　　要：目的 :建立一种简便可靠的大鼠胰岛素抵抗模型。方法 :对大鼠进行不同剂量地塞米松腹腔注射 ,观察不同时间各组大鼠糖代谢相关变化。结果 :大鼠空腹葡萄糖、胰岛素、胰岛素抵抗程度呈地塞米松给药时间及剂量依赖性 ,后两者改变先于前者改变。结论 :一定剂量的地塞米松空腹注射将诱发大鼠胰岛素抵抗 ,这种模型简便、可靠 。Aim:To build a easy and reliable rat model of insulin resistance. Methods:Changes concerning sugar metabolism were observed in experimental rats injected intraperitoneally by different doses of dexamethasone. Results:The changes by dexamethasone in fasting blood insulin and insulin resistance prior to that of fasting blood glucose were dose and time dependent. Conclusion:It was convenience to set up a insulin resistance model induced by dexamethasone in rats which would favor other related research.

关 键 词：胰岛素抵抗 地塞米松 大鼠 模型 

分 类 号：R587[医药卫生—内分泌]