衰老过程中原癌基因及抑癌基因的表达谱  

Expression Profile of Pro-Oncogenes and Tumor-Suppressor Genes in Celluar Senescence

作　　者：韩晓琳[1] 张宗玉[1] 童坦君[1] 

机构地区：[1]北京大学医学部生物化学与分子生物学系,北京100083

出　　处：《生理科学进展》2002年第2期126-130,共5页Progress in Physiological Sciences

基　　金：国家重点基础研究发展规划 (G19990 5 390 6 );国家教委博士点基金资助项目

摘　　要：细胞衰老时增殖能力逐渐减退 ,实质细胞不断减少 ,是脏器功能衰退的原因之一。原癌基因及抑癌基因与细胞增殖调控密切相关 ,因而它们与细胞衰老的关系早已引起人们的关注。本文就此进行了概括介绍。总的看来 ,衰老时多数原癌基因表达降低 ,抑癌基因表达增强 。Cellular senescence suppresses cell proliferation and the number of cells reduce gradually,which is one of the reasons of organisms exhaust. Pro-oncogenes and tumor-suppressor genes are associated with the regulation of cell proliferation.So the relationship of these genes and cellular senescence has caught the attention of investigators. Here we introduce briefly the expression of some pro-oncogenes and tumor-suppressor genes in the course of cellular senescence. It shows that most pro-oncogenes are down-regulated and tumor-suppressor genes are up-regulated. Some genes show differential expression in different types of cells.

关 键 词：衰老 原癌基因 抑癌基因 表达谱 

分 类 号：Q255[生物学—细胞生物学] Q419