脉冲式一氧化氮吸入流量控制仪的实验研究及临床应用  

Clinical Application and Experimental Studies of the Pulsed InhaledNitric Oxide Flow Controlling Instrument

作　　者：莫绪明[1] 赵恩春[1] 王敏生[2] 谷兴琳[2] 王振喜[3] 王春生[3] 

机构地区：[1]南京医科大学附属南京儿童医院心胸外科,江苏南京210008 [2]中国兵器工业总公司528厂 [3]上海医科大学中山医院心脏外科

出　　处：《中国医疗器械杂志》2002年第1期33-35,共3页Chinese Journal of Medical Instrumentation

基　　金：江苏省青年基金(BQ98005);江苏省卫生厅科研基金(H9741)资助。

摘　　要：设计了脉冲式NO吸入流量控制仪 ,对其工作原理进行了探讨 ,并进行了物理性能检测、动物实验及临床应用研究。物理性能检测结果表明 ,在不同压力下及不同释放量下NO实际释放量与理论释放量非常接近(p>0.05) ,均无统计学差异 ,能够达到临床应用要求。动物实验结果表明 ,吸入NO浓度与理论浓度相比偏低 ,但差异不显著(p>0.05)。16例PH病人吸入NO后平均PVR从617±51.3dyn.s.cm -5降至417±36.9dyn.s.cm -5(p<0.01) ,PAP从吸入NO前的54.4±13.1mmHg 降至33.8±12.3mmHg(p>0.01) ,但停止吸入NO后较短时间即回到基线。脉冲式NO吸入流量控制仪设计符合要求 ,可以被广泛地应用于临床及实验研究 ,从而为临床又提供了一个新的治疗途径。A flow controlling system for pulsed inhaled nitric oxide has been developed and tested,and here its features and initial animal experiments and clinical applications are described.The physical characteristic test indicates that the practical released dose of NO gas is very close to the theoretical flow of NO gas at variant pressures Animal experiments demonstrates that inhaled NO gas concentration is lower than the concentration of theoretical inhalation,but the variance is not remarkable(p>0.05).When sixteen cases with CHD and PH were chosen to inhale NO gas (15ppm,15min)PAP and PVR of all cases were reduced after inhalation of NO gas from 617±51.3dyn.s.cm_5,54.4±13.1mmHg to 417±36.9dym.s.cm_5,33.8±12.3mmHg(PVR,p<0.01;PAP,p<0.01)respectinely.When gas inhalation was stopped,these values returned to their base lines.aftrn a short period of time.All these show that the pulsed inhaled NO flow controlling instrument in accordance with the requirements of the designing,can be widely used in clinical diagnoses and treatments and will be a new tool offered for the treatments of the patients with PH.

关 键 词：先天性心脏病 一氧化氮 肺动脉高压 肺冲式气体流量控制仪 治疗 

分 类 号：TH789[机械工程—仪器科学与技术] R541.1[机械工程—精密仪器及机械]