实验性感染H9亚型禽流感病毒对鸡的免疫机能及免疫器官的影响  

Effect of Experimental Infection with H9 Avian Influenza Virus on the Immune System of Chicken

作　　者：陈义平[1] 吴力力[1] 万洪全[1] 许益民[1] 王宝安[1] 朱坤熹[1] 

机构地区：[1]扬州大学畜牧兽医学院,江苏扬州225009

出　　处：《中国兽医学报》2002年第2期153-154,共2页Chinese Journal of Veterinary Science

摘　　要：以 H9亚型禽流感病毒 (AIV) Ck/YZ株人工感染罗曼蛋鸡 ,在其免疫器官中仅引起法氏囊部分淋巴滤泡髓质区内的淋巴细胞轻度减少 ,而胸腺、脾脏、哈氏腺、盲肠扁桃体均未出现病变。与对照组相比 ,感染组鸡的外周血淋巴细胞在白细胞中的分类计数未出现明显变化。实验性感染 AIV Ck/YZ株后 ,再进行新城疫 系苗免疫 ,可引起罗曼蛋鸡血清中抗 NDV的 HI抗体滴度轻度下降 ,但免疫后 18d用 NDV强毒攻击时 ,仍能完全保护。The effect of experimental infection with an avian influenza A virus Ck/YZ strain(H9) on avian lymphoid tissues was demonstrated by histopathological examination.The result showed that slight lymphopenia appeared in some bursal medulla followed infection with Ck/YZ,but not appeared in thymus,spleen,Harder′s gland,cecal tonsil.Compared with the control group,the percentage of peripheral blood lymphocytes in blood white cells had nearly no change.Vaccinated with La Sota strain of Newcastle disease virus on day 7 post-infection with Ck/YZ,the titres of HI antibody against NDV slightly reduced,however,the protection rate was still 100% when challenged with velogenic NDV.

关 键 词：禽流感病毒 淋巴细胞 病理变化 鸡 免疫机能 免疫器官 实验性感染 H9亚型 

分 类 号：S852.65[农业科学—基础兽医学] S858.31[农业科学—兽医学]