噻氯匹啶对脑血栓病人的血栓烷B_2的抑制  

Inhibition of Ticlopidine to Thromboxane B_2 in Cerebral Thrombosis

作　　者：何扬[1] 阮长耿[1] 

机构地区：[1]江苏省血液研究所苏州医学院血栓与止血研究室

出　　处：《苏州医学院学报》1991年第3期176-178,254,共3页Acta Academiae Medicinae Suzhou

摘　　要：应用噻氯匹啶250mg/d 治疗急性脑血栓15例,疗程3个月。结果,血浆中血栓烷B_2浓度于治疗2周后开始持续性降低,对于ADP 诱导的血小板血栓烷B_2生成量,也有显著的抑制作用,提示噻氯匹啶的抗血栓作用与抑制血小板花生四烯酸代谢有关。15 patients with acute cerebral thrombosis were treated withTiclopidine at the dosage of250mg/d for three months.The alterations of TXB_2 level in plasma and platelet TXB_2 productioninduced by ADP were observed.Two weeks after administration of the drug,plasma TXB_2 level de-creased significantly and platelet TXB_2 production induced by ADP was remarkly inhibited.These(?)results suggest that the antiplatelet efficiency of Ticlopidine might be,in part,related to the inhibi-tion of arachidonic acid metabolism in platelets.

关 键 词：噻氯匹啶 血栓烷B2 脑血栓 血小板 

分 类 号：R973.2[医药卫生—药品]