小儿肾脏病尿THPβ_2-MG测定的临床意义  

Clinical significance of measuring THP β_2-MG contentin the urine for children glomerular disease

作　　者：狄为民[1] 王希竹[1] 杨风英[1] 

机构地区：[1]天津医科大学第二医院,天津300211

出　　处：《天津医科大学学报》2002年第1期87-89,共3页Journal of Tianjin Medical University

摘　　要：目的 :探讨小儿肾脏病尿THP、β2-MG测定的临床意义。方法 :选择小儿肾脏病102例 ,健康对照25例 ,用放射免疫法测定其尿THP、β2-MG的含量。结果 :肾功能不全组尿THP较对照组明显降低(P<0.01)。肾病综合征组和肾功能不全组尿β2-MG较对照组明显升高(P<0.01) ,而其中肾功能不全组尿β2-MG升高更明显 ,与肾病综合征组比较亦有显著性差异(P<0.01)。结论 :小儿肾小球疾病测定其尿THP、β2-MG的含量 ,可以了解肾小管损害程度 ,并早期发现肾功能不全 ,对观察疗效和判定预后有着重要的临床意义。Objective: To evaluate the clinical significance of measuring THP β2-MG content in the urine for children glomerular disease.Methods: RIA was used to determine THP β2-MG content in the urine for 102 children glomerular disease and 25 healthy control. Results: THP content in the urine of renal failure groups was significantly lower than those of control(P<0.01).β2-MG content in the urine of nephrotic syndrome groups and renal failure groups were significantly higher than those of control (P<0.01), and that of renal failure groups was the highest of them. While there were significant difference between both of them (P<0.01). Conclusion: Measuring THP β2-MG content in the urine for children glomerular disease may suggest the degree of renal tubular disorder,but also early find out renal failure. So it had important clinical significance to observe therapy effects and judge the prognosis of disease.

关 键 词：肾脏病 TAMM-HORSFALL蛋白 Β2-微球蛋白 儿童 

分 类 号：R726.92[医药卫生—儿科]