羟甲芬太尼对慢性缺氧大鼠呼吸的影响  

Respiratory effects of Ohmefentanyl in chronic hypoxic rats

作　　者：许欣 张明祥 张东 李歧爱 张殿尧[2] 王成海 

机构地区：[1]107医院,山东烟台264002 [2]长海医院呼吸内科,上海200433 [3]第二军医大学神经生物教研室,上海200433

出　　处：《实用医药杂志》2002年第3期204-205,共2页Practical Journal of Medicine & Pharmacy

摘　　要：目的 探讨μ阿片受体激动剂对慢性缺氧模型呼吸功能的影响。方法 正常大鼠侧脑室注射羟甲芬太尼（Ｏｈｍｅｆｅｎｔａｎｙｌ，ＯＭＦ）后，观察记录呼吸频率（ＲＲ）；侧脑室微量注射阿片受体拮抗剂纳洛酮（ＮＬＸ）、ＯＭＦ，测定ＲＲ、潮气量（ＶＴ）及血气指标，并对每分通气量（ＭＶ）与ＰａＣＯ２作线性回归分析。结果 正常大鼠侧脑室注射ＯＭＦ后，ＲＲ显著下降（Ｐ＜０．０５）。慢性缺氧模型侧脑室注射ＯＭＦ后显著降低ＲＲ、ＶＴ以及中枢对ＣＯ２的敏感性（Ｐ＜０．０１）。电性缺氧模型侧脑室注射ＮＬＸ后，ＲＲ显著增高（Ｐ＜０．０５），并可增强中枢对ＣＯ２的敏感性。结论 μ阿片受体激动剂通过与中枢阿片受体结合降低ＲＲ、ＶＴ等呼吸指标以及中枢对ＣＯ２的敏感性，从而显著影响慢性缺氧模型的呼吸功能。Objective To assess the role of Ohmefentanyl (OMF) in the physiological and pathophysiological process of respiratory regulation in chronic hypoxic rats. Methods The chronic hypoxic rat model was established by intravenous injections of papain 6 time ,once a week. All animal were pretreated with sodium pentobartital (35mg/kg) before experiment. Intracerebroventricular administrating naloxone (NLX) and OMF to the models, the respiratory rate(RR)and tidal volume(VT)and PaCO2 were measured. Results After the microinjection of NLX in chronic hypoxic rats, resulted in a marked increase in RR and central hypercapnic sensitivity. Intracebroventricular microinjection of OMF in chronic hypoxic models, resulted in a severe respiratory depression after injection of 15,30,45 ,60min. Conclusion These results indicate that the p. opiate receptor may be involved in central respiratory control of chronic hypoxic rats.

关 键 词：慢性缺氧症 呼吸 羟甲芬太尼 

分 类 号：R594.3[医药卫生—内科学]