硒对乙醇致大鼠机体损伤的保护作用  

STUDY ON EFFECTS OF SELENIUM ON ALCOHOLIC BODY INJURY OF RAT.

作　　者：石同幸[1] 聂木海[1] 诸茂盛[1] 麦惠霞[1] 

机构地区：[1]广州市疾病预防控制中心毒理科,广州510080

出　　处：《现代预防医学》2002年第2期186-187,共2页Modern Preventive Medicine

摘　　要：目的 :探讨硒对乙醇致体内脂质过氧化的保护作用及机理。方法 :用 3g/kg体重的乙醇给大鼠灌胃 ,同时自由饮用含硒量为 0 .2 5 mg/L 的亚硒酸钠水溶液 ,饲养三个月。结果 :与单给乙醇组比较 ,乙醇 +Se组大鼠组织和血清 MDA含量显著降低 (P均 <0 .0 1) ,GSH- Px、SOD、CAT活性均升高 (P均 <0 .0 5 )。结论 :硒可能通过增加 GSH- Px、SOD。Objective:To study the mechanism that selenium inhibited lipid peroxidation by alcohol causing in vivo.Method:To repeat ingestion alcohol in SD rats at the dose of 3g/kg weight,and fed with the dose of 0.25mg/L selenium(Se) at the same time in three months.Results:The contents of malondiadehyde(MDA) was decreased(P<0.01) and the activities of glutathione peroxidase(GSH-Px),superoxide dismitase(SOD),catalase(CAT) were increased in tissue and serum between alcohol+Se and alcohol groups(P<0.05).Conclusion:The selenium could inhibit the injury of over-dose alcohol to body by elevating activities of GSH-Px,SOD and CAT.

关 键 词：硒 乙醇 脂质过氧化 饮酒 

分 类 号：R994.4[医药卫生—毒理学]