二氧化钛纳米颗粒和雌二醇对小鼠子宫脏器系数和过氧化物酶活性的影响  

Effects of titanium dioxide nanoparticles and estradiol on uterine organ coefficient in mice and activity of peroxidase

作　　者：郑丽舒[1] 金一和[1] 张颖花[1] 

机构地区：[1]中国医科大学公共卫生学院,辽宁沈阳110001

出　　处：《中国工业医学杂志》2002年第2期83-84,共2页Chinese Journal of Industrial Medicine

摘　　要：目的　探讨二氧化钛 (TiO2 )纳米颗粒对 1 7β 雌二醇 (1 7β E2 )生物活性的影响。方法　去卵巢小鼠连续 3天 ,每日 1次同时腹腔注射纳米TiO2 [1 0 ,50 ,2 50mg/ (kg·d) ]和 1 7β E2 [0 0 2 μmol/ (kg·d) ]后 ,测定子宫脏器系数和过氧化物酶 (POD)活性。结果　同时给予纳米材料TiO2 和 1 7β E2 使小鼠子宫脏器系数和POD活性均升高。其中同时给予 1 0mg/ (kg·d)纳米TiO2 组增加比较明显 ,而 2 50mg/ (kg·d)纳米TiO2 组增加最少。结论　纳米TiO2 具有增强 1 7β E2 生物活性的作用。Objectives To study the effects of titanium dioxide(TiO 2)nanoparticles on the biological activity of 17β estradiol.Methods Uterine organ coefficient and activity of peroxidase in castrated female mice intraperitoneally treated with 10,50 and 250 mg/(kg·d) of TiO 2 nanoparticles and 0 02 μmol/(kg·d) of 17β estradiol,respectively,once daily for three consecutive days,were measured.Results Uterine organ coefficient and activity of peroxidase increased in the castrated female mice treated with both TiO 2 nanoparticles and 17β estradiol,the most in those with 10 mg/(kg·d) of TiO 2 and the least in those with 250 mg/(kg·d) of TiO 2.Conclusions TiO 2 nanoparticles could enhance the biological activity of 17β estradiol.

关 键 词：17Β-E2 子宫脏器系数 POD活性 纳米材料TiO2 纳米医学 

分 类 号：R319[医药卫生—基础医学] TB383[一般工业技术—材料科学与工程]