金叶败毒颗粒对HCMV感染及母婴垂直传播的临床疗效研究  

Clinical Therapeutic Effectiveness of Jinyebaidu against Human Cytomegalovirus Infection and Maternal-fetal Transmission

作　　者：曾万江[1] 闻良珍[1] 陈素华[1] 凌霞珍[1] 敖黎明[2] 刘兰清[3] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,武汉430030 [2]上海第二医科大学儿科研究所,上海200127 [3]中国医科大学附属第二医院儿科病毒研究室,沈阳110003

出　　处：《华中科技大学学报（医学版）》2002年第2期186-188,191,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家"九五"科技攻关资助项目 (No. 96 - 90 4- 0 6 - 0 8)

摘　　要：采用 EL ISA法筛查育龄妇女 2 32 0例及孕妇 34 88例血清中人巨细胞病毒 (HCMV) Ig M、Ig G,并以 Ig M阳性者作为研究对象 ;采用 RT- PCR技术检测孕中期脐血、羊水、孕晚期脐血中晚期 HCMV- m RNA,检测胎儿先天性感染。采用金叶败毒颗粒、更昔洛苇治疗 HCMV感染并与对照组 (Ig M自然转阴组 )比较 Ig M转阴率及垂直传播率。结果表明 :对育龄妇女金叶败毒颗粒治疗组、更昔洛苇治疗组其 HCMV- Ig M转阴率分别为 81.32 %、 10 0 % ,明显高于对照组 (4 8.0 8% ) ,差异具有极显著意义 (P<0 .0 0 1) ;两治疗组之间差异无显著意义。对孕妇金叶败毒颗粒治疗组其HCMV- Ig M转阴率为 80 .91% ,明显高于对照组 (39.81% ) ,差异具有极显著意义 (P<0 .0 0 1) ;金叶败毒治疗组母婴传播率为 19.6 4% ,明显低于对照组 (4 7.37% ) ,差异具有显著意义 (P<0 .0 5 )。提示 :金叶败毒颗粒是治疗 HCMV感染安全、有效的药物 ,能降低胎儿先天性 HCMV感染率 ,对孕妇Enzyme linked immunosorbent assay (ELISA) was used to screen serum human cytomegalovirus (HCMV) specific antibodies (IgM and IgG) in 2320 child-bearing aged women and 3488 pregnant women. The patients positive for HCMV-IgM served as the subjects. RT-PCR technique was used to detect the expression of late HCMV-mRNA in amniofluid, umbilical blood during the second semester and umbilical blood after delivery of HCMV-IgM positive pregnant women. Jinyebaidu (JYBD) and ganciclovir (GCV) were used through umbilical cord to treat the patients with HCMV infection. The patients without using any drugs served as control group. Results showed that the HCMV-IgM converse negative rate in child-bearing age women was 81.32 % , 100 % in JYBD group and GCV group respectively, very significantly higher than that of control group (P<0.001). No significant difference was found between two treatment groups (P>0.05). The HCMV-IgM converse negative rate in the pregnant women was 80.91 % in JYBD group, very significantly higher than that of control group (39.81 % ) (P<0.001). The vertical transmission rate was 19.64 % in JYBD group, significantly lower than that of control group (P<0.05). It was concluded that JYBD is a safe, efficient, specific drug to treat HCMV infection in the pregnant women.

关 键 词：人巨细胞病毒感染 金叶败毒颗粒 HCMV感染 母婴垂直传播 临床疗效 研究 

分 类 号：R285.5[医药卫生—中药学] R259.129.9[医药卫生—中医学]