高压氧治疗HIE及血浆TNF-α、ET-1水平变化的研究  

The Research on Treating HIE by HBOT and the Changes of TNF-α,ET-1 in Plasm.

作　　者：江凤霞[1] 王世俊[1] 钟亮[1] 

机构地区：[1]东莞东华医院儿科,广东东莞523000

出　　处：《中国儿童保健杂志》2002年第1期33-35,共3页Chinese Journal of Child Health Care

摘　　要：【目的】　探讨高压氧治疗对HIE患儿血浆TNF α与ET 1水平的影响及临床意义。　【方法】　高压氧治疗 4 1例HIE患儿 ,压力 0 .0 5～ 0 .0 7kPa ,加压、稳压、减压各 2 0分钟 ,共历时 1小时 ,每天 1次 ,疗程 10天。采用放射免疫法对 72例HIE患儿血浆TNF α与ET 1水平进行同期动态观察。　【结果】　中重度HIE患儿血浆TNF α与ET 1浓度显著高于对照组 (P <0 .0 1) ;轻度HIE患儿血浆TNF α与ET 1浓度与对照组比较无显著性差异。中重度HIE患儿经高压氧治疗后血浆TNF α与ET 1的降低幅度明显大于常规治疗组 (P <0 .0 1)。　【结论】　TNF α与ET 1参与了HIE的发病过程 ,高压氧治疗后血浆TNF α与ET 1的降低幅度明显大于常规治疗组 ,表明HBOT可能通过减少TNF α与ETTo investigate the changes of plasm tumor necrosis factor α and endothelin lin hypoxic ischemic encephalopathy(HIE) by hyperbaric oxygen treatment(HBOT) and clinical significance. Fourty one cases of HIE were treated by HBOT,pressure 0.05～0.07kPa,compression for 20 minutes,steady for 20minutes,decompression for 20minutes,total time was an hour,1 time a day,course was 10 days.Plasm TNF α and ET 1 of 72 cases of HIE were detected by RIA. The plasm TNF α and ET 1 of moderate and severe degree HIE group were significantly higher than control group;the plasm TNF α and ET 1 of mild degree HIE group had no significant differences compared with control group.The decreased range of plasm TNF α and ET 1 in moderate and severe degree HIE group by HBOT were significantly higher than routine therapy group. [Conclusion] Plasm TNF α and ET 1 were involved in the development of HIE process,HBOT could reduce the production of TNF α and ET 1 and protect brain cells from damage.

关 键 词：新生儿 缺氧缺血性脑病 高压氧 肿瘤坏死因子 内皮素 治疗 

分 类 号：R722.12[医药卫生—儿科]