铅在小鼠体内部分脏器中分布的实验研究  

Experimental study of the distribution of lead within some organs of laboratory mice

作　　者：龚建福[1] 黄贤仪[1] 陈晓霞[1] 

机构地区：[1]新疆医科大学公共卫生学院劳动卫生学教研室,新疆乌鲁木齐830054

出　　处：《新疆医科大学学报》2002年第1期29-31,共3页Journal of Xinjiang Medical University

摘　　要：目的 :观察铅在实验小鼠血、骨、肾中的分布情况及其与接触剂量之间的关系。方法 :用微分电位溶出法对不同剂量组的染铅小鼠 ,分别于第 30、6 0、90天随机抽取数量相等的小鼠处死 ,取其血、骨、肾 ,用微分电位溶出仪测其铅的含量。结果:各实验时段 ,血铅含量均随剂量的递增而增高 (P <0 .0 1) ;骨、肾铅含量的递增和染毒时间的延长而增高 (P <0 .0 5 ) ,且均与血铅呈正相关。结论 :血铅能较好地反映近期铅接触水平、骨和肾中铅的含量变化及铅的蓄积规律。Objective: To observe (1) the distribution status of lead in the blood,in the bone and kidney tissue of laboratory mice and (2) the relationship between the amount of lead administered and the distribution status. Method: Three equal-numbered groups of mice were administered different amounts of lead over pre-determined periods of time. After 30 days,one group of mice were killed and the kidney tissue and blood of these mice were tested for the presence of lead by means of the Lead Amount Measuring Test, using a microthermal analyzer. After 60 days and 90 days the other groups were killed and tested, respectively. Result: (1)Blood.In each of the three experimental stages,the amount of lead in the blood increased directly with the increase of administered lead (P<0.01), but the amount of lead did not accumulate with time in the blood. (2)Bone and kidney tissue. In the bone and kidney tissue,the same result was found, except that the amount of lead did accumulate and correlate with long-term lead exposare (P<0.05). Conclusion: The amount of lead in the blood of laboratory mice reflects only the effect of recent lead exposure. That is, blood can throw off the lead. The amount of lead in bone and kidney tissue reflects the effect of long-term lead exposure. That is, these tissues can not throw off the lead.

关 键 词：小鼠 醋酸铅 脏器分布 铅中毒 

分 类 号：R595.202[医药卫生—内科学]