静脉滴注单硝酸异山梨酯治疗心绞痛的疗效及安全性  

Observation of Effects and Safety of the Therapy with Intravenous Drip of Isosorbide Mononitrate Injection in Patients with Angina Pectoris

作　　者：李士玉[1] 马玉玲[2] 冯国伟[1] 郭向杰[1] 李志鸿[1] 张玉柱[1] 

机构地区：[1]济宁医学院附属医院急诊科,济宁272129 [2]济宁医学院生化教研室,济宁272129

出　　处：《中国临床药理学杂志》2002年第1期7-11,共5页The Chinese Journal of Clinical Pharmacology

摘　　要：目的：观察静脉滴注单硝酸异山梨酯对冠心病心绞痛的疗效及安全性。方法：冠心病心绞痛患者随机分为单硝酸异山梨酯大剂量组 （Ａ组）、小剂量组（Ｂ组）和硝酸甘油对照组 （Ｃ组），每组５０例，分别静脉滴注单硝酸异山梨酯４０ｍｇ和２０ｍｇ，硝酸甘油１０ｍｇ，均为每日一次，１０－１４日为一疗程。结果：Ａ组总有效率为 ９４％，Ｂ组为 ９２％，Ｃ组为 ７８％。三组比较，Ａ组和 Ｂ组均明显优于Ｃ组，Ａ组和Ｂ组比较无显著性差异。结论：静脉滴注单硝酸异山梨酯对冠心病心绞痛疗效较好，药物不良反应较少，是治疗冠心病心绞痛安全有效的药物之一。OBJECTIVE: To investigate the effects and safety of the therapy with intravenous drip of isosorbide mononitrate injection in patients with angina pectoris. METHODS:The patients with angina pectoris were randomized to receive large dose of isosorbide mononitrate injection (group A),low dose of isosorbide mononitrate injection(group B) and nitroglycerine (group C) , with 50 patients in each group. The patients in A , B and C group received intravenous drip of isosorbide mononitrate injection (40mg and 20mg) and nitroglycerine(lOmg) respectively once a day, the course of therapy was 10-14 days. RESULTS: The effective rates were 94%,92% and 78% respectively in A,B and C group.The effective rates of group A and group B were much higher than that of group C(P<0.01),and it had no difference between group A and group B(P>0.05). CONCLUSION: Intravenous drip of isosorbide mononitrate injection in patients with angina pectoris was the significantly effective therapy with drug advorse reaction,so the isosorbide mononitrate injection was one of the safe and effective drugs for treating angina pectoris.

关 键 词：单硝酸异山梨酯 硝酸甘油 心绞痛 

分 类 号：R541.405[医药卫生—心血管疾病] R972.3[医药卫生—内科学]