左旋四氢巴马汀对苯丙胺条件性位置偏爱效应的影响  

Effect of l-tetrahydropalmatine on the conditional place preference produced by amphetamine

作　　者：周媛[1] 邢淑华[1] 

机构地区：[1]徐州医学院药理学教研室,江苏徐州221002

出　　处：《徐州医学院学报》2002年第2期105-107,共3页Acta Academiae Medicinae Xuzhou

基　　金：江苏省教育厅资助课题 (0 1KJD310 0 11)

摘　　要：目的　观察左旋四氢巴马汀 (l-tetrahydropalmatine ,l-THP)对苯丙胺 (Amphetamine,AA)的条件性位置偏爱 (conditionalplacepreference,CPP)效应的影响。方法　采用倾向性训练程序训练大鼠 ,建立位置偏爱模型和建立氢化可的松诱发位置偏爱效应重现模型 ,并观察l-THP对其影响。结果　l-THP 10mg·kg-1可阻断AA 2 .0mg·kg-1的位置偏爱效应 ,并且可阻止氢化可的松 10mg·kg-1诱发的位置偏爱效应的重现。结论　AA可使大鼠出现条件性位置偏爱效应 ,并在一定剂量范围内 (0 .5～ 4.0mg·kg-1)呈量效关系 (r=0 .94) ;氢化可的松可使已消失的位置偏爱效应重现 ;以上 2种效应均可被l-THP阻断。Objective To observe the effects of l-tetrahydropalmatine (l-THP) on the conditional place preference (CPP) produced by amphetamine (AA).?Methods Tendentious training program was adopted to establish the rat conditional place preference model, and hydrocortisone was used to reestablish the CPP model.?Results l-THP 10 mg·kg -1 could prevent the CPP induced by AA 2.0 mg·kg -1 and could hold back the reestablishment of CPP induced by hydrocortisone 10 mg·kg -1 .?Conclusion AA can induce CPP on rats in dose-effect manner within certain dose range (0.5～4.0 mg·kg -1 )(r=0.94). Hydrocortisone can be used to reestablish the faded CPP. Both of the above two events can be prevented by l-THP.

关 键 词：左旋四氢巴马汀 苯丙胺 条件性位置偏爱 非麻醉性镇痛药 影响 

分 类 号：R971.1[医药卫生—药品]