^(99m)Tc-DTPA巯甲丙脯酸肾显像对糖尿病患者肾功能的临床评价  

Clinical Evaluation of Captopril-interventional Renal Imaging for Renal Function in Patients with Type 2 Diabetes Mellitus

作　　者：董萍[1] 张遵城[1] 郑妙瑢[1] 肖连东[1] 苏如松[2] 

机构地区：[1]天津医科大学第二医院核医学科,300211 [2]天津医科大学第二医院内科,300211

出　　处：《天津医药》2002年第4期198-200,共3页Tianjin Medical Journal

摘　　要：目的:了解巯甲丙脯酸(Captopril)介入肾显像,对评价糖尿病患者肾脏血流和功能变化的临床价值。方法:对15例正常对照和46例血压正常的2型DM患者进行了基础肾显像(BRI)和巯甲丙脯酸介入肾显像(CRI),测量介入前后的肾小球滤过率(GFR)、峰时(Tp)、半排时间(T1/2)、20分残留率(C20)。结果:DM较对照组GFR增高,Tp、T1/2逐渐延长,C20增加。介入前后对照组的血压、GFR、Tp、T1/2、C20无明显改变。DM患者血压略下降,GFR均降低,DM1组Tp、T1/2缩短,C20降低。DM2组Tp缩短,T1/2、C20无明显变化。DM3组Tp、T1/2均延长,C20增高。结论:CRI可灵敏、准确地反映分肾功能和血流情况的变化,对DM的分期、判断疗效、指导治疗等有重要价值。Objective: To evaluate the effects of captopril on renal hemodynamics and function in patients with type 2 diabetes mellitus (DM). Methods: Both basic renal imaging (BRI) and captopril-interventional renal imaging (CRI) were performed in 15 normal controls (NC) and 46 normal blood pressure (BP) patients with type 2 DM. The glomerular filtration rate (GFR), peaktime (Tp), half activity time (T1/2), and 20 minute remain rate (C20) of the renogram were measured simultaneously. Results: GFR significantly increased in DM group compared with that in control group (P< 0.01). Tp and T1/2 of the renogram gradually prolonged, and C20 increased in DM patients. After captopril was intervented, there was no significant change in BP, GFR, Tp, T1/2 , and C20 in NC group. In DM group, BP decreased slightly and GFR significantly decreased (P<0.01). Compared with BRI, Tp and T1/2 were significantly shortened in DM 1 group (P<0.05), and C20 significantly decreased (P<0.05). In DM2 group, Tp was shortened, and there was no significant change in T1/2 and C20. In DM 3 group, Tp and T1/2 significantly delayed (P<0.01), and C20 increased respectively (P<0.01). Conclusion: Captopril-interventional renal imaging is a sensitive and accurate method in measuring split renal hemodynamics and function, it may be helpful for differentiating the clinical stages, estimating the curative effect, and instruction the treatment of patients with type 2 DM.

关 键 词：^99MTC-DTPA 巯甲丙脯酸 肾显像 糖尿病 肾功能 临床评价 

分 类 号：R587.1[医药卫生—内分泌] R817.47[医药卫生—内科学]