同型半胱氨酸、叶酸、维生素B_(12)与妊娠高血压综合征发病的关系  

Investigation of relationship between pregnancy induced hypertension syndrome and homocysteine, folic acid and vitamin B_(12)

作　　者：黄泳华[1] 罗中明[1] 朱伟淑[2] 张群[1] 阮晓红[1] 钟倩[1] 

机构地区：[1]广东省江门市中心医院妇产科,529070 [2]广东省江门市中心医院检验科,529070

出　　处：《中华妇产科杂志》2002年第4期208-210,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的　探讨同型半胱氨酸 (Hcys)、叶酸、维生素B12 与妊娠高血压综合征 (妊高征 )发病的关系。方法　采用荧光偏振免疫分析法检测 5 9例妊高征患者 (妊高征组 )和 6 0例正常晚期妊娠妇女 (对照组 )血清中Hcys水平 ;并同时用微粒子酶联免疫分析法检测两组孕妇血清中叶酸、维生素B12水平。结果　 (1)妊高征组孕妇血清Hcys水平为 (13 1± 3 7) μmol/L ,对照组孕妇为 (10 4± 3 9)μmol/L ,两组比较 ,差异有显著性 (P <0 0 5 )。 (2 )妊高征组孕妇血清叶酸、维生素B12 水平分别为(12 9± 4 0 ) μmol/L及 (339 5± 115 6 ) μmol/L ;对照组孕妇叶酸、维生素B12 水平分别为 (13 7± 2 5 )μmol/L及 (35 0 1± 15 3 0 ) μmol/L。两组比较 ,差异无显著性 (P >0 0 5 )。结论　Hcys代谢异常在妊高征发病中起重要作用 ,叶酸、维生素B12Objective To investigate the relationship between pregnancy induced hypertension syndrome (PIH) and homocysteine, folic acid and vitamin B 12 Methods There were 59 cases of PIH (group A) and 60 cases of normal late pregnancy were enrolled (group B) The serum homocysteine level was detected with flurescence polarization immunoassay (FPIA), serum folic acid and vitamin B 12 levels were detected with microparticle enzyme immunoassay (MEIA) Results There was significant difference ( P <0 05) of serum homocysteine levels between group A[(13 1±3 7) μmol/L] and group B[(10 4±3 9) μmol/L] Although, the level of folic acid and vitamin B 12 in group A were lower than those of group B, there was no statistical differences between the two groups( P >0 05) Conclusion It was concluded that the disorder of homocysteine metabolism may play an important role in the pathogenesis of PIH, and no direct evidence to prove that folic acid and vitamin B 12 were related with PIH

关 键 词：妊娠并发症 心血管疾病 妊娠高血压 高半胱氨酸 叶酸 维生素B12 病因 

分 类 号：R714.246[医药卫生—妇产科学]