肾络通对梗阻性肾病模型大鼠血管活性物质作用的研究  

Effects of Shenluotong on Vasoactive Substances in Obstructive Nephropathy Rats

作　　者：谷艳丽[1] 荣英蕊 

机构地区：[1]保定市第一中医院,河北保定071000 [2]涿州市中医医院,河北涿州072750

出　　处：《四川中医》2014年第6期73-75,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察肾络通对梗阻性肾病模型大鼠肾组织血管活性物质的作用,为肾络通的临床应用提供实验依据。方法:健康雌性SD大鼠40只,随机分为假手术组(SHAM)、模型组(UUO)、缬沙坦治疗组(UUOV)、肾络通治疗组(UUOS),每组10只。观察各组动物病理学改变;放免法检测TXB2、6-keto-PGF1α、ET-1、NO的含量。结果:肾络通可减轻大鼠肾脏病理形态学的改变,降低TXB2、6-keto-PGF1α、ET-1、NO的含量。结论:肾络通可有效改善肾脏病理损伤,对梗阻性肾病模型大鼠有良好的治疗作用。Objective： Observing Shenluotong on vasoactive substances in renal tissue of rats with obstructive nephropathy model role, to provide experimental evidence for clinical application of Shenluotong. Methods： 40 healthy female SD rats were randomly divided into sham operation group （SHAM）, model group （UUO）, valsartan group （UUOV）, Shenluotong therapy group （ UUOS）, 10 rats in each group. Observing the pathological change of each animal; content radioimmunoassay in TXB2, 6-keto-PGF1 ct, ET-1, NO. Results： Shenluotong can reduce renal pathological changes in rats; and reduce the content of TXB2, 6-keto-PGFlot, ET-1, NO. Conclusion： Shenluotong can effectively improve the renal damage, has a good therapeu- tic effect on obstructive nephropathy rats.

关 键 词：梗阻性肾病 肾络通 血管活性物质 

分 类 号：R285.5[医药卫生—中药学]