小青龙汤对过敏性鼻炎大鼠作用机制的研究  

Research on the Mechanism of Xiaoqinglong Decoction to Allergic Rhinitis Rats

作　　者：李丹[1] 胡长庚[2] 马露[2] 吕妍[1] 

机构地区：[1]天津医科大学总医院中医科,天津300052 [2]天津医科大学,硕士研究生天津300052

出　　处：《四川中医》2014年第6期76-79,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察小青龙汤对过敏性鼻炎大鼠作用机制。方法:采用卵蛋白对大鼠的全身致敏与局部攻击的方法制备AR模型。随机分为5组,空白对照组,模型组,中药高、中、低剂量组,每组9只。空白对照组为正常大鼠。中药各组分别灌服2.1g/kg、1.575g/kg、1.05g/kg小青龙汤,1次/天,连续14天。以治疗前后的行为学体征积分、鼻黏膜切片病理变化、血清LTC4、IL-12、IgE的含量作为观测指标。结果:小青龙汤能有效改善AR大鼠症状积分(P<0.01),修复受损的鼻黏膜,降低血清LTC4、IgE水平(P<0.01),提高AR大鼠血清IL-12含量(P<0.01),且高剂量效果最优。结论:小青龙汤对AR模型大鼠具有多靶点抗鼻过敏反应作用。Objective ： To research the mechanism of Xiaoqinglong Decoction on allergic rhinitis rats. Methods ： To produce the AR model by ovalbumin systemic sensitization and local attacks. The rats were randomly divided into normal group, model group, Xiaoqinglong Decoction high-dose group, Xiaoqinglong Decoction middle-dose group, Xiaoqinglong Decoction low-dose group, nine in each group. Traditional Chinese Medicine groups were taking 2. 1 g/kg, 2. 1 g/kg, 1.05 g/kg Xiaoqinglong De- coction, once a day, continuous gavage for ld days. To determine the characteristics of the behavior, the change of rat nasal mucosa pathophysiology and the content of IgE, IL-12, LTC4 in serum before and after treatment. Results： Xiaoqinglong De- coction could effectively improve the symptoms of AR rats integral （P 〈0. 01 ）, repair the damaged nasal mucosa, reduce the content of IgE, LTC4, improve the content of IL-12 in serum, and the high dose effect optimal. Conclusion： Xiaoqinglong De- coction has multiple anti-allergic targets for AR model rats.

关 键 词：过敏性鼻炎 小青龙汤 

分 类 号：R285.5[医药卫生—中药学]