心脉龙注射液抗衰老作用的实验研究  

An Expermental Study on Anti-senilitg Effect of Xinmailong

作　　者：吴建新[1] 钮荣祥[1] 黄秀群[1] 田昆仑[1] 董丛丽[1] 

机构地区：[1]大理医学院生理学教研室,云南大理671000

出　　处：《贵阳医学院学报》2002年第2期125-127,共3页Journal of Guiyang Medical College

基　　金：云南省教委应用基础研究基金资助课题 (2 0 0 1 0 71 6)

摘　　要：目的 :观察纯中药制剂心脉龙 (XML)注射液的抗衰老作用。方法 :XML按 6mg/kg、8mg/kg体重给老年小鼠连续腹腔注射 30d后 ,测定血清过氧化氢酶 (CAT)、超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶(GSH -Per)活性 ,测定脑组织丙二醛 (MDA)、脑组织和肝脏脂褐质 (Lf)的含量。结果 :XML两剂量组均能显著提高老年小鼠血清CAT、SOD、GSH -Per活性 ,降低老年小鼠脑组织MDA含量、降低脑和肝组织Lf含量。结论Objective:To observe the anti senility effect of Xinmailong(XML) on old mouse.Methods:The activity of serum catalase(CAT)?superoxide dismutase(SOD)?glutathione peroxidase(GSH-Per);the malondialdehyde(MDA) of brain tissue,and lipofuscin(Lf)contents in brain tissue and liver of old mice were determined after thay were given(ia) XML for 30 days at doses of 6*#mg/kg and 8*#mg/kg resrectively. Results:The activity of serum CAT?SOD?GSH Per in old mice obviously increased,while the contents of MDA of brain tissue and liver decreased.Condusion:XML has an effect of anti senility through improving free radicals.

关 键 词：心脉龙注射液 抗衰老作用 实验研究 过氧化氢酶 超氧化物歧化酶 谷胱甘肽过氧化酶 丙二醛 中药 

分 类 号：R285.5[医药卫生—中药学]