肿瘤坏死因子受体在人精子的表达及其意义  

Expression of TNF receptor in human spermatozoa

作　　者：白文俊[1] 侯树坤[1] 王晓峰[1] 闫征[2] 何培英[2] 田世河 邓庆平[1] 

机构地区：[1]北京大学人民医院泌尿外科,100044 [2]北京大学人民医院中心实验室,100044 [3]山西省汾阳医院泌尿外科

出　　处：《中华泌尿外科杂志》2002年第3期179-180,共2页Chinese Journal of Urology

摘　　要：目的　证实肿瘤坏死因子受体 (TNF R2 )在人精子有表达 ,为TNF α对精子的直接作用提供实验证据。　方法　用Western印迹法检测TNF R2 在 15例生育者精子的表达。　结果　 15例生育者的精子均有TNF R2 表达。　结论　TNF R2 在人精子有表达 ,该受体可能参与了TNFObjective To verify the presence of tumor necrosis factor receptor (TNF R 2) in spermatozoa of fertile men,and to provide experimental evidence for the direct action of TNF on spermatoza. Methods Using Western blotting the expressions of TNF R 2 in spermatozoa of 15 fertile men were assessed. Results TNF R 2 was expressed in spermatozoa of all the 15 fertile men. Conclusions The spermatozoa of fertile men have TNF R 2,which may transmit the cytokines signal into cytoplasm and modulate the spermatozoa function.

关 键 词：精子 肿瘤坏死因子 受体 WESTERN印迹法 信号转导 精子功能 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]